Devastating New Data From PHE Shows Vaccine Effectiveness Down to 17% and No Reduction in Infectiousness – But Mortality Cut by 77%
Public Health England yesterday released their latest technical briefing on the variants of concern, number 20, and it has some illuminating data.
It provides us with the infection, hospitalisation and death rates for the Delta variant, broken down by vaccination status and age. This allows us to do a calculation of the real-world vaccine effectiveness in the over-50s during the Delta surge, albeit a rough one without any adjustments.
The latest report has data up to August 2nd. If we substract from these values the data in Briefing 17 (up to June 21st) then we get the data covering the period June 22nd to August 2nd, which broadly corresponds to the bulk of the Delta surge in the U.K. The vaccine rollout to the over-50s was basically complete by this point, having stabilised according to PHE at around 88% double vaccinated and 10% unvaccinated (the other two per cent remaining single vaccinated, perhaps due to a bad reaction to the first dose).
In this period the PHE data tells us there were 2,464 Delta cases in the unvaccinated over-50s and 17,926 in the fully vaccinated over-50s. From this we can estimate the vaccine effectiveness against infection in the over-50s during the Delta surge as 17% (1-[(17,926/88%)/(2,464/10%)]). This confirms using additional data the estimate I made last week.
We can make a similarly rough calculation of the vaccine effectiveness against death. Between June 22nd and August 2nd, PHE reports that among the over-50s there were 339 deaths with the Delta variant in the double vaccinated and 167 in the unvaccinated. Using the same proportions vaccinated and unvaccinated as above, this gives a vaccine effectiveness against death in the over-50s during the Delta surge of 77% (1-[(339/88%)/(167/10%)]). Interestingly, this is very similar to the latest estimate of vaccine effectiveness against serious disease from Israel, which is around 80%. This is a decent level of protection and helps explain why the Delta surge had proportionally fewer hospitalisations and deaths, but it is well below the levels suggested by earlier studies and quoted by PHE, which are north of 95%.














