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British Variant Not More Deadly, Admits PHE

by Will Jones
31 March 2021 10:14 PM

Contrary to claims since January that the Kent coronavirus variant is “up to 100%” more deadly, a new study from Public Health England has confirmed – as a Lockdown Sceptics‘ analysis showed three weeks ago – that it is no more deadly than the original virus. The study continues to claim it increases the risk of hospitalisation by 30%, but this too seems unlikely to be more than a statistical artefact. As the Swiss Doctor notes, it is based on poor evidence, and “the influence of age, comorbidities and seasonal effects is much larger”.

Lockdown Sceptics noted on Saturday that while the British variant is becoming dominant in many countries, that dominance is often, as in the UK and Denmark, accompanied by infections, hospitalisations and deaths plummeting not surging. President Macron is locking down France again for a month (including closing schools), blaming the surge on the British variant. But is this correct? Here’s the graph plotting the progress of the Kent variant across the channel.

SARS-CoV-2 variant prevalence in France – Kent variant in red (from CoVariant)

Here’s what the positivity rate does at the same time.

Notice how it declines from the end of January to mid February, despite the British variant by that point being in the driving seat (some of the drop around Christmas may be due to a temporary change in testing practice). It then goes up again from late Feb, but the increase is steady – the sharp rise in raw case numbers in the past three weeks is driven mainly by an increase in testing.

This isn’t to say that the new variants do not bring new challenges. The Swiss Doctor observes that a number of the variants (though not the British one) have shown evidence of partial immune evasion, at least in terms of antibodies.

Nevertheless, some of the new coronavirus variants – most notably the ‘South African’ variant – are beginning to show partial immune evasion, as was to be expected. Some monoclonal antibodies already fail to neutralise some of the new variants, and most vaccines achieve lower neutralisation, too. Pharmaceutical companies will respond to this by creating new therapeutic antibody combinations and by updating their coronavirus vaccines (a multi-billion dollar business).

In fact, by March 2021, the novel coronavirus has managed to escape two out of three major antibody classes. If a new strain manages to escape all three major antibody classes, this “would be a worrying development, and should be monitored closely”. (Greaney et al.) This is one more reason why progress in early and prophylactic treatment is so very important.

To be sure, antibody immune evasion doesn’t necessarily mean complete immune evasion, as the immune system has additional means to fight off infections, including the famed T cells.

The Swiss Doctor’s latest is worth reading in full.

Tags: British variantFrancePublic Health EnglandVariants

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11 Comments
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Annie
Annie
4 years ago

So when the Fascist pigs want to terrify their own people, each scariant is deadlier than the last, including the Kentiscariant. But when Macron wants to score a point against Britain (how very novel for a French leader!), our Fascists suddenly find that the Kentiscariant is a tame lapdog.
Well well.

12
0
peyrole
peyrole
4 years ago

I am not giving Macron a ‘pass’ here, he should have resisted the enormous pressure from his ‘experts’ that sometimes make SAGE look like poodles. But in his speech he was careful not to phrase reference to the Kent ‘variant’ as if it was a ‘britsh/brexit’ issue, which is how most of the UK MSM and this article are painting it. This doesn’t help anyone.
I agree that the almost linear rise in ‘cases’ is more a function of increase tests than anything else, but its also reflected in numbers of hospitalisations and ICU admissions, again in a linear increase.
This is highly unusual behaviour for a virus. There is no explanation I have seen for this.
I suspect some of the numbers are very suspect, and are part of an attempt to convince at least part of the 50% of the French population that are saying no to vaccination.

10
0
Matt Dalby
Matt Dalby
4 years ago

If people will need a booster jab in September that’s billions more in profit for big pharma and another reason to reintroduce restrictions if there is a seasonal rise in cases before everyone has their booster. I wonder who is lobbying who to push the largely nonexistant dangers of all these variants.
Since viruses continously mutate, and presumably have done for hundreds of millions of years it seems obvious that the immune system would evolve to be able to fight variants of a virus as well as the strain that is currently circulating. Any organism that was immune against new variants and not just the old one would have a competative advantage and be more likely to pass on the genes for developing this immunity. This is another reason why it would’ve been better to allow the virus to spread among people at low risk of serious illness. Natural herd immunity is likely to be better than vaccine induced immunity. Sadly this is one more basic principle of biology/virology that the “experts” seem to have ignored, for reasons only they can know.

11
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Annie
Annie
4 years ago
Reply to  Matt Dalby

Not yet.

7
0
sophie123
sophie123
4 years ago
Reply to  Annie

A few months ago someone leaked the contract. They can choose to make a profit from July, if I recall correctly

4
0
karenovirus
karenovirus
4 years ago
Reply to  sophie123

It depends on who gets to call the end of the emergency at which point
1. AstraZeneca can start charging market rates.
2. Authorisation for use under ’emegency’ provisions must surely be called into question ?

0
0
RickH
RickH
4 years ago
Reply to  karenovirus

… which gives the rationale for continually upping the ante in terms of new Scary Fairies, and continuing the suppression of possible cheap prophylactics like Ivermectin.

2
0
www
www
4 years ago
Reply to  Matt Dalby

They are experimenting on millions of subjects for free, whilst getting lots of coverage, that’s a nice win-win

1
0
Harrison Bergeron
Harrison Bergeron
4 years ago

Your link to the PHE study is hilariously, embarrassingly wrong.

It is actually the link to a BMJ study (March 10) concluding that the Kent variant is indeed much more deadly.

Please provide the correct link.

1
0
AHotston
AHotston
4 years ago
Reply to  Harrison Bergeron

Yes – even in the report written by the “Swiss Doctor” there is only a link to an article in the Daily Telegraph. The study seems not to have been published (or peer reviewed) yet, and its existence is only known due to a press conference at 10 Downing Street.

0
0
swedenborg
swedenborg
4 years ago

There could be an easy explanation for increased hospitalization rate not accompanied by higher mortality rate. The propensity to admit could have been increased compared to the first wave ie less sick cases admitted. The health care sytem did not collapse in the first wave might increase “overhospitalization” ie doctors admit more,knowing it would have less effect on the system. Really the excess mortality and the the true C-19 mortality is the only way to estimate if a variant really is more dangerous.

The Swizz doctor is a bit leaning to van den Bosche scenario saying if neutral antbodies are affected as above could be problematic although they allude to something called T-cells immunity. But another study published a few days ago,again showed that T cells have a broad immunity incl. against variant.
One would bet that natural acquired immunity ,is the most effective T cells response as known by everybody pre 2020 and that an artificial immunity like vaccine can never come up to that level. The article above is down here

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab143/6189113#.YGTXD75sdDQ.twitter

CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals (n=30) potentially maintain recognition of the major SARS-CoV-2 variants suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

3
0

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