People with severe obesity generate a significantly weaker immune response to COVID-19 vaccination compared to those with normal weight, but the previously infected do not have this problem, a study has found. The study was conducted by Professor Volkan Demirhan Yumuk from Istanbul University and colleagues and was presented at the European Congress on Obesity in the Netherlands last week. SciTechDaily has more.
Obesity is a disease complicating the course of COVID-19, and the SARS-CoV-2 vaccine antibody response in adults with obesity may be compromised. Vaccines against influenza, hepatitis B, and rabies, have shown reduced responses in people with obesity…
Researchers measured antibody levels in blood samples taken from patients and normal weight controls who had received two doses of either the Pfizer/BioNTech or CoronaVac [Sinovac] vaccine and had their second dose four weeks earlier. The participants were classified by infection history as either previously having COVID-19 or not (confirmed by their antibody profile)…
In those without previous SARS-CoV-2 infection and vaccinated with Pfizer/BioNTech, patients with severe obesity had antibody levels more than three times lower than normal weight controls (average 5,823 vs 19,371 AU/ml).
Similarly, in participants with no prior SARS-CoV-2 infection and vaccinated with CoronaVac, patients with severe obesity had antibody levels 27 times lower than normal weight controls (average 178 vs 4,894 AU/ml).
However, in those with previous SARS-CoV-2 infection, antibody levels in patients with severe obesity and vaccinated with Pfizer/BioNTech or CoronaVac were not significantly different from normal weight controls (average 39,043 vs 14,115 AU/ml and 3,221 vs 7,060 AU/ml, respectively).
With obesity a major predictor of serious disease and death in Covid patients, that’s not good news for vaccine efficacy.
Worth reading in full.
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So when the Fascist pigs want to terrify their own people, each scariant is deadlier than the last, including the Kentiscariant. But when Macron wants to score a point against Britain (how very novel for a French leader!), our Fascists suddenly find that the Kentiscariant is a tame lapdog.
Well well.
I am not giving Macron a ‘pass’ here, he should have resisted the enormous pressure from his ‘experts’ that sometimes make SAGE look like poodles. But in his speech he was careful not to phrase reference to the Kent ‘variant’ as if it was a ‘britsh/brexit’ issue, which is how most of the UK MSM and this article are painting it. This doesn’t help anyone.
I agree that the almost linear rise in ‘cases’ is more a function of increase tests than anything else, but its also reflected in numbers of hospitalisations and ICU admissions, again in a linear increase.
This is highly unusual behaviour for a virus. There is no explanation I have seen for this.
I suspect some of the numbers are very suspect, and are part of an attempt to convince at least part of the 50% of the French population that are saying no to vaccination.
If people will need a booster jab in September that’s billions more in profit for big pharma and another reason to reintroduce restrictions if there is a seasonal rise in cases before everyone has their booster. I wonder who is lobbying who to push the largely nonexistant dangers of all these variants.
Since viruses continously mutate, and presumably have done for hundreds of millions of years it seems obvious that the immune system would evolve to be able to fight variants of a virus as well as the strain that is currently circulating. Any organism that was immune against new variants and not just the old one would have a competative advantage and be more likely to pass on the genes for developing this immunity. This is another reason why it would’ve been better to allow the virus to spread among people at low risk of serious illness. Natural herd immunity is likely to be better than vaccine induced immunity. Sadly this is one more basic principle of biology/virology that the “experts” seem to have ignored, for reasons only they can know.
Not yet.
A few months ago someone leaked the contract. They can choose to make a profit from July, if I recall correctly
It depends on who gets to call the end of the emergency at which point
1. AstraZeneca can start charging market rates.
2. Authorisation for use under ’emegency’ provisions must surely be called into question ?
… which gives the rationale for continually upping the ante in terms of new Scary Fairies, and continuing the suppression of possible cheap prophylactics like Ivermectin.
They are experimenting on millions of subjects for free, whilst getting lots of coverage, that’s a nice win-win
Your link to the PHE study is hilariously, embarrassingly wrong.
It is actually the link to a BMJ study (March 10) concluding that the Kent variant is indeed much more deadly.
Please provide the correct link.
Yes – even in the report written by the “Swiss Doctor” there is only a link to an article in the Daily Telegraph. The study seems not to have been published (or peer reviewed) yet, and its existence is only known due to a press conference at 10 Downing Street.
There could be an easy explanation for increased hospitalization rate not accompanied by higher mortality rate. The propensity to admit could have been increased compared to the first wave ie less sick cases admitted. The health care sytem did not collapse in the first wave might increase “overhospitalization” ie doctors admit more,knowing it would have less effect on the system. Really the excess mortality and the the true C-19 mortality is the only way to estimate if a variant really is more dangerous.
The Swizz doctor is a bit leaning to van den Bosche scenario saying if neutral antbodies are affected as above could be problematic although they allude to something called T-cells immunity. But another study published a few days ago,again showed that T cells have a broad immunity incl. against variant.
One would bet that natural acquired immunity ,is the most effective T cells response as known by everybody pre 2020 and that an artificial immunity like vaccine can never come up to that level. The article above is down here
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab143/6189113#.YGTXD75sdDQ.twitter
CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals (n=30) potentially maintain recognition of the major SARS-CoV-2 variants suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.