Several datasets have shown what appears to be negative vaccine effectiveness against infection – of higher infection rates among the vaccinated than among the unvaccinated. While this was phenomenon was initially ascribed to the use of incorrect denominators when estimating infection rates, it’s now too widespread to ignore.
One possible explanation for negative vaccine effectiveness is original antigenic sin – a property of the immune system’s response to some viruses.
When the immune system encounters a novel pathogen, it responds to the pathogen’s antigens. Original antigenic sin means that when it encounters a related version of the pathogen, it may respond to the antigens carried by the original version. The result is weaker immunity.
If original antigenic sin exists for the Covid vaccines, then vaccinated people might actually have weaker immunity against certain variants – either now or in the future – because the vaccines have ‘programmed’ their immune systems to target the Wuhan strain.
While a number of sceptics and other ‘non-mainstream’ commentators have mentioned original antigenic sin in this context, we haven’t heard much about it from ‘mainstream’ commentators.
One exception was an op-ed written by three virologists, two of whom resigned from the FDA when the Biden Administration approved booster shots for 16 and 17 year olds without consulting a key advisory panel. In the op-ed, Philip Krause and colleagues point out that “boosting on the original antigen could be counterproductive”.
More recently, original antigenic sin found its way into the New York Times – America’s ‘newspaper of record’. “Some experts have raised concerns,” the article notes, that getting boosters too often “may even be harmful”. And one “plausible” reason why is “original antigenic sin”.
The article goes on to quote Harvard vaccine scientist Amy Sherman as saying, “We have enough clues that it could be a problem.”
There’s certainly no proof that original antigenic sin exists for the Covid vaccines. But the evidence is growing. And it’s summarised in this detailed piece for the Epoch Times by Todd Zywicki. He concludes:
More evidence will be needed before one can raise definitive concern about the risk of OAS with respect to the SARS-CoV-2 vaccines. But theory, laboratory evidence, and clinical analysis all point to this as a rapidly emerging risk of the current SARS-CoV-2 vaccines, and one that could be exacerbated by widespread application of booster shots,
As to the alternative explanation that’s been put forward for higher infection rates among vaccinated people – that they take more risks – Zywicki offers a comprehensive rebuttal:
Reams of data and studies demonstrate that not only are these suppositions groundless, they are also exactly opposite to reality. Studies demonstrate what everyday experience during the pandemic tells us – that vaccinated individuals are much more likely to fear SARS-CoV-2 more than unvaccinated and more likely to take precautions against potential COVID-19 infection.
Original antigenic sin ought to be getting a lot more attention from public health authorities. In the meantime, Zywicki’s article is worth reading in full.
Discussion
Comments
This week across the site:
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And here is another
https://www.thegatewaypundit.com/2022/01/omicron-transmission-likely-facilitated-vaccines-dr-malone-warns-keep-vaccinating-risk-developing-pathogenic-virus-video/?utm_source=Email&utm_medium=the-gateway-pundit&utm_campaign=dailyam&utm_content=daily
Smoke and mirrors.
No way they have created enough vials for to jag everyone. Clearly there are ‘covid’ vials and probably a flu vaccine in many others.
There is an ivermectin panic on the big tech and MSM right now. Massive articles from MSM on Ivermectin trying to push a danger narrative and also negative press on Americans Frontline Dr’s, again, to keep the Covid narrative alive. Just go to the Goog and type ivermectin then look at all the panic news articles. We are over the target. Big-Pharma is panicking. This medicine has been widely used by humans without any problems for 40 years. It’s inventor won a Nobel Prize after 20 years of successful use and after 100 million people were cured of a broad spectrum of problems without any side effects. Get your Ivermectin while you still can! https://ivmpharmacy.com
“Original Antigenic Sin” postulates that the “cure” is worse than the disease. Basically, it tells us that the opposite of what was supposed to happen will happen.
This rings true to me. With any government solution, I expect the Law of Opposite Effects to kick in at some point.
I’d add that nearly all properly designed vaccine effectiveness trials (matched cohort based) show negative VE for two doses of vaccine.
Tripe doses are rapidly heading the same way.
For some reason governments worldwide seem to only want to report TNCC studies, that have an inherent bias in situations where there is mass testing (this is warned about in all methodology reviews; governments prefer to ignore the warnings).
Yawn
Ah fuck it I’ve given up on this shit show. Pork pie head clown BoJo should be deposed just for this.
I have found this pre-introduction to the immune system. The story of the child born without an immune system in 1971 is eye opening, especially what happened after he had a bone marrow transplant from his sister in 1984. Intro to Immunology Springboard – YouTube
Georgia had her first dose of Pfizer “vaccine” on May 13, 2021. Afterwards she said: “It wiped me out. I felt like I could have slept for a year. I felt like that for a couple of days”.
Then, amazingly, she went back and got a second dose, and this time she said: “Within four hours I felt dizzy and light-headed. I fainted that evening, and in the following days, I fainted up to three times each day”.
Was the first dose of toxin not enough to warn her? When did people come to believe that medications should make you seriously ill before curing or protecting you?
The formerly young and fit Georgia is now a practical cripple. She’ll never work or lead a normal life again.
I have normal levels of empathy, but I’m finding it harder and harder to have sympathy for people that went against all the evidence and had themselves poisoned anyway. And even here on The Daily Sceptic there are idiotic commenters who still believe that any poisonings were accidental.
Georgia published a video on Instagram showing herself struggling to walk around her home. The Times and Daily Mail found this video and ran stories about it that insinuated that Georgia had solely posted it as an anti-vax gesture.
Neither of these publications mentioned that Georgia’s health problems began in the immediate aftermath of her getting “vaccinated”. The trolls read these articles in The Times and Daily Mail and then started attacking Georgia for being an anti-vaxxer.
Then Instagram threw her off their platform ‘because the video of her struggling to walk denigrated the “vaccines”.’
It reads like a real bad comedy that an inbred group of yokels would attempt to put on in their parish hall.
And this is the modern UK.
These “journalists” who will not tell the truth and indeed try to smear people who are trying to tell the truth must be exposed. They are a disgrace to their professions.
Great read. See some journalists actually do their jobs. But note these are always freelance journalists.
So the idea is to soften people up with a “vaccine” and then release the big-time killer pathogen? Who’d have thought it?
Today I learnt: Boris Johnson’s father Stanley Johnson (who married Jenny Sieff from the family that controls Marks and Spencer) has written books including
As for Stanley’s son:
Yet he won’t be an example of his own stated values?
If I have understood this correctly. The presumption behind this is that because the mRNA and the alterations to the chimpanzee adenovirus are based purely on the coding for the antigens of one or two strains of SARS-CoV-2 that a different strain that has modified genes that present the antigens will escape the vaccine. However, surely that new strain is still vulnerable to being detected by dendritic cells as if it were a brand new virus, and the innate system would still work. That is how the innate system works. The new variant has to get past the physical and chemical barriers first in any case. This could cause a cough, sneezing, runny nose. There may be an inflammatory response leading to fever, tiredness and reduced appetite. If the virus has managed to infect a few cells then T cells in the tissue will destroy them. This is the innate system, no antibodies required. If glands in the neck, groin, arm pits become swollen then the adaptive system is being primed by dendritic cells.
Vaccine Enhanced Disease is considered something of a mystery amongst accinologists.
Still roll up your sleeve for another booster, I’m sure it will all be dandy, and if it isn’t you won’t know anything about it.
Shhh! No one tell Macron. He won’t be able to send the unrepentant to work camps if this gets out.
Does Macron still dare to walk the streets of Paris on his own I wonder?
He hasn’t the incentive of his predecessor to ride on the the back of a moped to see his mistress – apparently though he “consults” his Mama in the rooms below his Office in the Élysée every two hours, before he makes any decision.
If Zemmour’s ‘Union of the Right’ project comes to pass, Macron is toast – if they fight with each other as usual then he will be back – God help the French.
Getting rid of him is their only hope.
Macron is WEF trained and funded so he will have the full support of the MSM.
I’m sure Macron has some butch bodyguards to look after his needs
And yet they keep boosting against new variants with a ‘vaccine’ designed to be effective against the original wild type from 2 years ago. And if you don’t get boosted, at least in France so far, but wait for the usual lockstep to take hold, you are a non person.
The irony being that if you do keep taking the boosters you soon will be a ‘non person’ – in a very real sense!
So Catch 22?
There is now enough evidence of damage and danger worldwide on every front to withdraw these jabs and close down the forced vaccination programme …but nothing is done and ye propaganda continues regardless
That tells us all we need to know.
In short: the are not being used for the benefit of mankind – in fact quite the opposite.
But in the UK, the political establishment have seen the writing on the wall before others??
I think Japan saw it first, to give them credit.
Who else is regaining sanity? us (maybe), Ireland (maybe)….where else? Mexico? (no vaccine requirements to enter)
India? (with their ivermectin packs)
Bidenstan can’t even see the wall.
Japan recognises life saving ivermectin – banned by Johnson Javid and Whitty!
Our lot actually murdered patients with established toxic doses of HCQ in order to discredit it is a valid treatment.
If HCQ was seen to offer a remedy they wouldn’t be able to force the public into taking the injections.
Boris should hang.
I thought so (and was thinking about emigrating there!) but I’ve read they’ve ‘gone back into lockdown’ – it’s a truly baffling picture globally….
As far as I know they are still jabbing ….Kids next!
In New Zealand in 2017 an experiment was conducted on rabbits where they were inoculated with a vaccine which had been created from a variant of a Coronavirus – this particular virus was supposedly a zoonotic, i.e., it had made the jump from animal to human.
The inoculated rabbits became sick and developed antibodies against this virus. When animals or humans develop antibodies against a particular virus, they are usually neutralising antibodies, which means that if they encounter the same virus again, or a variant of it, these antibodies kill it completely.
But the antibodies the New Zealand rabbits developed were not the usual variety. These rabbits developed non-neutralizing or binding antibodies. When the inoculated rabbits were infected with the variant of Coronavirus the vaccine was based on, these binding antibodies actually made pathways for the virus to enter and replicate in the rabbit’s cells.
One reason why this particular vaccine may have caused the rabbits to develop such weird and self-defeating antibodies, is that the variant of Coronavirus its creation was based on had been genetically manipulated in a laboratory. That scientists somewhere had used gain of function to purposefully make this virus more virulent and… Read more »
“Designed to give the inoculated AIDS” – at last we have an ‘objective’ and ‘successful outcome’ match for the vaccines!
The Wuhan strain? There were about 78,000 genetic variations in early 2020, with ~300 in the UK alone. If there was a ‘Wuhan strain’, it mutated away rapidly as the virus ensemble mutated to reach its final endemic form where the virus coexists with its host.
The worldwide genetic variants map shows this process in action.
I seem to remember a thing called the precautionary principle. Presumably it died of Covid some time ago, because it sure as hell doesn’t apply to the snake oils.
Or died *with* COVID …
With the Global Multi -Vax Roll out still proceeding, won’t that eventually be everybody?
But then isn’t that the Big Idea?
The abject failure of the MHRA to protect us should be a ‘sacking matter’ at the very least – perhaps more a cleaning of the stables?
But I expect only the “Cleaning Lady” will lose her job ( for poor time keeping)..
The words AGENCY CAPTURE should be shouted from the rooftops. Most people have no idea it even exists, I’ve learned.
Mmm, I can’t see how exposing us to the same 2019 era[*] spike protein over and over again is helping us against 2022 variants.
And I’ve not aware of any “vaccines” that need to be administered four times in a year, or whether that’s likely to result in our immune systems no longer recognising the pathogen (or related variants) as a threat.
What I do know is that annual influenza vaccines result in negative efficacy over time.
https://pubmed.ncbi.nlm.nih.gov/32276801/
Maybe it’s time for even the most fervent Branch Covidian to stop taking the sacrament while they still can.
[*] … or earlier.
naa just let them take it. Had enough attempting to convince
Anecdotally I’ve just watched a Covidian zealot in my workplace tie himself up in knots when trying to explain to a more agnostic colleague why the boosters would be effective against a different virus. It was very entertaining indeed. Said nothing of course.
How did they even try?!
Oh it was completely pitiful. Something about having so many antibodies that they overpowered the virus even though they didn’t exactly fit. Didn’t do much for the agnostic’s hesitancy!!
Reminds me of my PhD educated friend explain to me that, yes, the vaccinated can spread the virus but less than unvaccinated. How I hear you ask? Well, apparently, the vaccinated only spread it through their skin now, you know, touching cash and the rest. The unvaccinated do this too, but also breathing out virus. The vaccines eliminate this as a source of transmission.
I laughed, asked him where on earth he got that from. He couldn’t quite remember.
The vaccine spike proteins operate in a different way from those in the – virus , they are far more dangeous!
Discovery identifies a highly efficient human reverse transcriptase that can write RNA sequences into DNA — ScienceDaily
Imagine the effect if this happens often with mRNA jabs?
Exactly! Time will tell.
I do worry about what happens when the scales fall from the eyes.
What does seem clear is that the more frequent the jabs the greater all the risks.
Direct yourself to the latest Pfizer press release. They’ll put your mind to rest.
Original Antigenic Sin, Antibody Dependent Enhancement, Vaccine Acquired Immunodeficiency Syndrome etc. plus all the other possible side effects from the experimental jab including myocarditis people will be potentially more ill from the jab than they would be from Covid.
I think this must now becoming crystal clear to even the most dense among us!
West is drumming up Ukraine conflict. Seems to be (no surprises) only coming from one side (our side). Could this be the path to them the blame of skyrocketing inflation on “conflict”?
It’s just another episode in the long history of painting Russia as our primary enemy when our primary enemy is actually Western governments who are at war with their own populations, and our secondary enemy is the CCP who are infiltrating Western governments and other public bodies like our universities.
The BS stinks to heaven ( for anyone with a political/historical nose and an ‘O’ level in Geography – sadly a shrinking minority. )
We wait for the inevitable US “CIA/ Black Ops” False Flag.
I do wonder if they will try to sabotage the Nordstream pipeline the US Deep State hates so much?
Yes … it is all total BS cooked up by the CIA as a cover for Biden’s senility, Voter Fraud and Covid Vax oppression in the US, which only works because the ignorant population knows absolutely nothing about Russia and the Ukraine.
Putin will stay cool – he knows he is dealing with psychotics.
Notions like this won’t catch on.
it goes against the narrative.
how can politicians explain how this works when it flies in the face of what they’ve been shovelling the past 2 years.
how can Sajid go on tv and announce he’s stopping boosters and because they don’t work with the new variant. He’d have to stop all cv vaccines. People will then remind us that while omicron is the variant de jour, the others are still out there and it will be claimed the vaccIne is stopping those from spreading.
If the government eventually decides not to booster any more they will never admit it. They will say that ‘boosters’ will now be given annually, starting this autumn, alongside flu vaccines. As long as they don’t make them compulsory (it really wouldn’t make sense to do so, seeing the flu jab isnt, mind you, sense and government aren’t two words that sit well together). I hope though that eventually the shit will hit the fan about how dangerous and useless the vaccines are. Surely this has got to happen sometime?
2nd February perhaps, when thousands of people up and down the country go to their local police station to report the crime.
Looking at all the adverse reactions and other data I eould guess between 2 and 5 years for the long term health problems to show up
One suggestion is six years off the life expectancy of the jabbed .
Javid is a worthless stooge – he will say anything.
Yes – one possibility.
But, still, let’s keep it simple : the very history of this snake oil means that safety and efficacy cannot be assured from any point of view.
We should treat them like they treated us. Prove you are unjabbed or be banned from Pubs, restaurants and large events.
Because, that’s the science right?
The shedding of the spike protein by the jabbed will probably be the greatest risk of infection – until they release the next more deadly virus that is.
This is now a war not a battle.
How sure are we about this ‘shedding’ thing? I was once spoken to like I was a dirty disease factory by one of the righteous jabbed, but wasn’t sufficiently sure of my facts to argue back to the contrary. Even GPs are propagating the ‘dangerous unvaxxed’ rubbish, I understand.
I think the virologists who have advanced the ‘shedding’ argument are looking at the way spike proteins are being produced in billons in all the cells of the ‘vaccinated’ and that they will probably leach out through bodily fluids and therefore can be transmitted by close proximity – whether or not they have aerosol capability I do not know.
We need some reputable virologist’s opinion
I think the evidence is still being collected . But we are now openly and brazenly told that the vaccinated can both acquire and transmit the ‘virus’ and after all the lies we have been subjected to, confusing the ‘virus’ with the shedding of pathogenic Covid spike proteins seems just like something they would now deliberately do to conceal the alarming “shedding”.
I’m no expert virologist, more an immunologist, but if you are one of the lucky survivors (99.9%) of covid, you’ve nothing to worry about re the vaxxed or variants of concern for that matter.
The human immune system (yes it’s better than that of other species on the planet) is pretty clever – and it has a good memory.
Certainly better than the best bigpharma can do.
Thanks – I recall something some months back about not using a big cubicle too soon after a jabber (how are we supposed to know?) I think we need to know about this, but I don’t want inadvertently to give an excuse to re-mandate masks; although if it comes out via perspiration and – ahem- flatus- masks wouldn’t help.
Ban the establishment from their jets and yachts, not ordinary people who were fooled.
We need truth and reconciliation not revenge.
I thought Original Antigenic Sin was a descriptive property of how the immune system operates, not a properly of individual vaccines. Or am I wrong?
https://pubmed.ncbi.nlm.nih.gov/28479213/.
Agreed – but the question is to what extent OAS occurs for the antigens created by the SARS-CoV-2 vaccines, how variable this response is, and the time period over which it occurs/wanes.
As was repeatedly pointed out at the start of this farrago people go mad in crowds and come to their senses one by one. Slowly people are doing just that. And as they do they give others the confidence to join in. What starts as a trickle soon becomes a steady flow and suddenly becomes a torrent. In 6 months time no one will have been in favour of vaccines, lockdowns or any of the paraphernalia of covidism. This article telling the masses what we sensible folk knew a year or more ago is just evidence of that direction of flow.
Please be right!
wish I could see it among the people I know – sadly, I am afraid their take on it will be, well I got covid again, because the booster had waned [or didn’t work] so I need another jab to “protect me” from getting the deadly plague
How many times were we warned of the dangers of vaccinating during a pandemic? Oh that’s right their voices were silenced by the ‘paid for MSM’ who accused them of being anti vaxxers and conspiracy theorists! Chickens haven’t yet fully come home to roost, but they will!
Our “dangers” are their “successful project”!
this clever fella explains in simple terms the problems with the ‘safe and effective vaccines’ safety trials, see the first few minutes…
https://rumble.com/vt5o9b-mi-robert-kennedy-jr-full-speech.html
More evidence will be needed before one can raise definitive concern about the risk of OAS with respect to the SARS-CoV-2 vaccines.
It used to be very different, for very good reasons.
Just in time; Pfizer’s share-price was starting to slip…
https://www.marketwatch.com/articles/fourth-covid-vaccine-dose-older-adults-study-51643020681?mod=mw_latestnews
Absolute Bollox.
More BS same suckers!
The only thing boosted is pfiser’s share price.
And the bank balance of so many well-known UK “experts”
OAS is part of it, the fact Natural Immunity beats any sub-unit vaccine by a country mile is another part. There’s also very strong indications the mRNA jabs interfear with innate immune response, in a similar way way HIV does (possibly because it contains at least 3 seperate HIV genomic sequences).
So if you were a national leader (i.e. WEF regional manager) and had pushed these jabs on your population, your top priority would be to eliminate any control group.
Without a control group, the ensuing health problems can be blamed on … covid!!
Indeed, I just made the same point in the other thread.
https://dailysceptic.org/2022/01/24/macron-says-no-vaxx-no-citizenship-as-france-unveils-new-stricter-vaccine-passports/#comment-709414
Yes that’s been the game for some time now. Part of the solution would be to eliminate the WEF regional managers.
I think this is a very sensible plan. Who is the UK’s representative?
Oh god it’s all of them isn’t it!? That’s why I think people of the world need to have their own anti-Davos summit.
What venue can accommodate 7 billion?
Or do we just wait until the Gates Plan is ‘executed’?
As you pointed out yesterday, it may have to be a zoom summit.
I hate zoom.
I hear Mexico doesn’t require anything for entry now. The Cancun Anti-Davos Summit. It’s got legs.
Love that! Visited the Yucatan in 2000 – Tulum would make a great venue.
Definitely not doing it on Zoom.
And yet in the UK, they have proudly attempted to publish the difference between vaxxed and unvaxxed cohorts in weekly surveillance reports – so they must have believed the drugs would work. It’s almost incomprehensible. Occam’s razor suggests that the Big Pharma arm of Global Totalitarian Inc. have BADLY let the side down – it must surely have been hoped at the outset that the drugs would at least give the appearance of working?!
Zooming out, this feels almost like a human computer virus. As though all of humanities worst traits – greed, hubris, the pursuit of power – have combined in an act of utter insanity. A Tower of Babel moment.
I think they did. Remember I used to work for a vaccine company. Not one making a covid vaccine (currently anyway). The senior management TOTALLY believed the jabs worked. They are mean to be the experts…they are nothing of the sort.
Some of the smarter analysts covering the sector know there is an issue, but they are not allowed to write about it. Two from Nordea got suspended for it. Most of them just take stuff at face value though, and I haven’t met one yet who has said no to the jab. They all think I am a bit nuts (and likely to be fired).
Corporate groupthink at work then. Terrifying. Maybe this whole thing is just the sum of too much corporate influence, and this is nothing more than a disastrous product launch…
Their bonuses depend on the jabs working!
The securing of their place in Heaven depended on Catholic Cardinals believing in the Virgin Birth! ( At least it did when they were Christians and not just “Marxists in a Frock”).
I pay close attention to what Bill Gates says publicly. He’s the high priest of the Global Totalitarian Inc.
He’s been out doing the rounds recently admitting the current jabs don’t do much and that the pharma’s need to produce better versions.
I think they know they have time. They can beat people over the head with boosters and vax passes for a few months until they come out with version 2.0.
Then the media machine will be put into top gear to tell everyone how marvellous v 2.0 is. And it will take another 6-12 months for the world to discover otherwise, by which time they’ll have v 3.0…. etc.. etc.,, etc….
This who live by and still believe in the “Media Machine” are destined to die by it!
I think we may have “allies”* even better hidden than our enemies, making people over play their hand too early.
*I don’t think their on “our” side, but they don’t want these fools to unset their apple cart.
It all seems very billion dollar brain to me.
But isn’t that just fighting talk?! How can they maintain the pretence of a ‘public health emergency?’ Surely the momentum is lost?
Propagandists don’t believe in anything other than successful lying.
Exactly what they have done!
Indeed – when do we substitute “solid hard evidence” for “strong indication” – they cannot keep the lid on this much longer.
Although perhaps a diversionary “War with Russia” would do the trick?
Truss has been made to look such a fool. “PM materal” ? God help us!
Sub unit vaccines are not new as shown below:
“Subunit and conjugate vaccines only contain parts of the organism used to stimulate an immune response. They also cannot cause infection and are safe for immunocompromised patients. Examples of subunit and conjugate vaccines are:
From https://zerotofinals.com/paediatrics/infectiousdisease/vaccinations/
Indeed, the propaganda would have us believe all vaccines are the same, and all viruses respond in the same way to immune system challenge.
Switching to sub-unit rather than LAV is much cheaper to produce, mRNA is cheaper still, yet both sub-unit and mRNA require multiple shots, and each shot is still sold at a price above the original LAVs, nice business model!!
I had Hep B vaccination in 1994 and required a booster some 15 years later. I had the pertussis as an infant, but I suspect that that wasn’t the same as the current one. My daughter who is pregnant has had another pertussis vaccination, despite having her childhood vaccines. When I looked at the online training to become competent in vaccination, one phrase stood out about the pertussis vaccine, that vaccine induced immunity was longer lasting than immunity through infection. It was the only one where that was claimed.
and one patented sequence from moderna..
It can’t have come from anywhere BUT a lab.
How to BLAST your way to the truth about the origins of COVID-19
I read that previously, ethical skeptics phylogenetic analysis still stands in the context of ‘viral swarms’ IMO.