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Conditional on Infection, the Vaccine May Not Protect Against Death in Over 60s

by Noah Carl
22 November 2021 3:16 PM

In a recent article, I noted that vaccine effectiveness against death may have been overestimated due to the ‘healthy vaccinee’ effect – the tendency for people who get vaccinated to be healthier and more risk-averse than those who don’t.

Likewise, Will Jones recently reported on a large Swedish study, which observed declining effectiveness against severe outcomes, particularly after six months. Discouragingly, the decline in effectiveness was most pronounced among older, frail individuals ­– the group most at risk from Covid.

Now a new study (which hasn’t yet been peer-reviewed) has made a similar finding. Maxime Taquet and colleagues analysed data from a large database of electronic health records in the U.S.

Their sample comprised ~19,000 individuals who’d had a confirmed SARS-CoV-2 infection between January 1st and August 31st 2021. There were two groups: those who had been vaccinated at least 14 days prior to infection, and those who had not been vaccinated prior to infection.

The two groups were matched not only on basic demographic characteristics, but also on a large number of medical risk factors. In addition, the unvaccinated individuals were selected from among those who’d ever received a flu vaccine. Overall, substantial efforts were made to ensure the two groups were comparable.

Taquet and colleagues’ main finding is shown in the figure below. The lines on each chart show the cumulative probability of death for vaccinated and unvaccinated people, respectively. (Note: they also looked at other severe outcomes; see Fig. 3.)

The chart on the left indicates that, on average, vaccinated people had a lower risk of death than unvaccinated people. However, as the other two charts indicate, this difference was seen primarily in those under 60. Among those over 60, it was small and not statistically significant. The authors note:

Receiving 2 vaccine doses was associated with lower risks for most outcomes. Associations between prior vaccination and outcomes of SARS-CoV-2 infection were marked in those < 60 years-old, whereas no robust associations were observed in those ≥ 60 years-old.

Why would vaccination have a stronger effect among those under 60? The researchers speculate that:

In younger patients, effective B-cell response to vaccination might be followed by infection with variants against which antibodies have less neutralising activity … In older patients, the B-cell response to vaccination might itself be ineffective

It’s important to keep in mind that their finding concerns the risk of death conditional on SARS-CoV-2 infection. To the extent to that the vaccine protects against infection, it will protect against serious illness and death too.

However, it’s still noteworthy that effectiveness against death in over 60s was minimal among those who had been infected. Of course, this is just one study, so it shouldn’t be given too much credence. But the researchers did make substantial efforts to ensure the two groups were comparable and thereby obviate the ‘healthy vaccinee’ effect.

If their finding is true, it would suggest that previous observational studies have overestimated vaccine effectiveness against severe outcomes in older age-groups. It would also suggest that most of the protective effect for these age-groups comes from immunity against infection, which we know wanes rapidly in the absence of boosters.

The evidence from Taquet and colleagues’ paper could therefore be taken as supporting voluntary boosters for high-risk groups, as well as the continued build-up of natural immunity in the rest of the population.

Tags: BoosterNatural immunityVaccines

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66 Comments
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steve_z
steve_z
3 years ago

well covid doesn’t really affect the under 60s. its only really interesting the vaccine effect in the terminally ill because that’s who’s dying of covid

19
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Peter W
Peter W
3 years ago
Reply to  steve_z

Expanding on that, Steve, the vaccines would always appear to work well in under 60’s because their natural immune system will stop or lessen infection. Those older are more likely to have poorer immune systems so more likely to be affected.

5
0
Chris_uk
Chris_uk
3 years ago

Allowing young healthy people to build natural immunity is the only way we will ever get out of the pandemic. Vaccinating everyone will only prolong the pandemic, and is incredibly dangerous. What happens to a virus that can circulate indefinitely in hosts that neither die nor become properly immune? We don’t know, because it has never been tried before. By all means protect the vulnerable, but we must allow people who are willing to take the risk to catch the virus and become immune.

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-1
steve_z
steve_z
3 years ago
Reply to  Chris_uk

its going through our primary school like crap through a goose. half my daughters class are off

4
0
RickH
RickH
3 years ago
Reply to  steve_z

Just think if that had been allowed to happen last year – we would have a tremendous reservoir of real immunity.

In my grand daughter’s case, children are being sent home at the emergence of a sniffle, even when known to have had SARS. Doh!

Last edited 3 years ago by RickH
22
-1
steve_z
steve_z
3 years ago
Reply to  RickH

yes. we would have been done by now. closing schools (and universities) was moronic

24
-1
karenovirus
karenovirus
3 years ago
Reply to  steve_z

They didn’t close down Universities, just tried and failed to stop students ‘mingling’ in the way that students do, with fantastic results.

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-2
Julian
Julian
3 years ago
Reply to  karenovirus

They were to all intents and purposes closed – campuses largely off limits, most or all teaching online, social and club/society activities and trips shut down, various restrictions in uni accommodation. A shit experience.

14
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karenovirus
karenovirus
3 years ago
Reply to  Julian

A shit experience no doubt but it didn’t prevent them mingling round our way.
When the entire student body were asked to test prior to going home for Xmas all bar 6 were found to be negative having recovered and so safe to share Xmas lunch with Granma.

3
0
John001
John001
3 years ago
Reply to  RickH

If AIUI it’s no more dangerous to children than chickenpox, why’s the policy not the same as for chickenpox? (aka let people live as normal.)

4
0
Julian
Julian
3 years ago
Reply to  steve_z

Not that it’s overly important but am curious to understand why it didn’t do that last year. Was it school closures, delta variant or simply more testing now?

3
0
realarthurdent
realarthurdent
3 years ago
Reply to  Julian

I think the vaccines caused it. They caused the delta variant to appear in the first place (the virus mutating in a successful attempt to evade the vaccine), and the vaccinated caught the Delta variant in their droves but were less symptomatic than the unvaccinated. They were therefore the superspreaders responsible for the most recent “wave” amongst younger people.

12
0
karenovirus
karenovirus
3 years ago
Reply to  realarthurdent

I’m nostalgic for the Kent variant that was looming on the horizon a year ago.
What is Latin for
I came
I saw
I disappeared?

Veni
Vidi
?

Last edited 3 years ago by karenovirus
5
0
steve_z
steve_z
3 years ago
Reply to  Julian

in peak 1 in march 2020 I knew about 3 people that had covid mildly

almost everybody I know had it in the last 6 months – mainly double vaxxed

I had it milder than anyone I know and unvaxxed – my unvaxxed wife had it even milder (tickly throat for a day)

12
0
HelzBelz
HelzBelz
3 years ago
Reply to  steve_z

Same here – OH jabbed and Covid tested positive a couple of weeks ago as have a number of colleagues in the last couple of months. Me, unjabbed and exposed to all of these people, not even a sniffle!

14
0
karenovirus
karenovirus
3 years ago
Reply to  steve_z

As advised by irrelevant NHS 111 recorded message en route to getting put through.

‘Most people who contract Covid19 will experience minor symptoms comparable to a cold. Please stay indoors and self medicate with over the counter flu and cold remedies’.

If that doesn’t spell it out, nothing will.

Last edited 3 years ago by karenovirus
12
0
realarthurdent
realarthurdent
3 years ago
Reply to  steve_z

By virtue of being at a state school with lots of parents who work in the NHS, I think it has already been through everyone in my kids’ classes; parents as well. Parents have given up on masks and are ignoring the head teachers request to keep wearing them in the playground. It’s over in that school, despite the best efforts of the authorities to keep the panic alive.

17
0
steve_z
steve_z
3 years ago
Reply to  realarthurdent

our primary is totally normal. lots of covid, no masks, no special rules, no shits given by anyone

16
0
karenovirus
karenovirus
3 years ago
Reply to  steve_z

As per usual since mass schooling began, just like Freshers flu?

5
0
NickR
NickR
3 years ago
Reply to  steve_z

Are any ill? The most sensible course would be to get them all infected asap then get back to normal.

0
0
cornubian
cornubian
3 years ago
Reply to  Chris_uk

The only ‘pandemic’ we witnessed was a pandemic of PCR false positives.

19
0
RW
RW
3 years ago
Reply to  Chris_uk

What happens to a virus that can circulate indefinitely in hosts that neither die nor become properly immune?

It’s promoted to a proper, unicelluar organism. 🙂

Viruses cannot do this because they aren’t bacteria and are not capable of independent reproduction. Virus replication works by killing host cells as a side effect (slightly simplified), hence, the only way to stay healthy after getting infected with one is immune system stops virus reproduction by eliminating it and the only other possible outcome is death.

6
0
amanuensis
amanuensis
3 years ago
Reply to  Chris_uk

I note a sentence in the recent UKHSA vaccine surveillance reports:

recent observations from UK Health Securit Agency (UKHSA) surveillance data that N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination.

This suggests that the vaccinated are not forming a complete immune response when they become infected with covid19. Given that the vaccines give all vaccinated people an identical immune response (to the original spike protein from 2 years ago) it is rather likely that once fully vaccine escape variants come along they will find it more difficult to form an effective protection (this is almost certainly Original Antigenic Sin in action).

This will likely have the effect of prolonging this epidemic and increasing the impact of each infectious season once it becomes endemic.

By vaccination everyone we look to have made things worse for everyone.

21
0
peyrole
peyrole
3 years ago
Reply to  amanuensis

But its not about what they say its about.
‘Worse for everyone’?…..not quite.

3
0
Chris_uk
Chris_uk
3 years ago
Reply to  amanuensis

Yes, that’s what I was alluding to. It’s an incredibly dangerous experiment to perform on the entire world population. At the very least, vaccinating the world with a “leaky” vaccine almost certainly prolongs the pandemic. At worst .. we just don’t know what happens.

4
0
karenovirus
karenovirus
3 years ago
Reply to  Chris_uk

‘Allowing young people to build natural immunity is the only way to get out of the pandemic . . .’

We would never have been in a ‘pandemic’ if they had taken note of S.Korea before UK Lockdown one.

Initially they had been reporting X per hundred mortality (hospitalisations/deaths) until they randomly tested several hundred of thousands of citizens and found that a high proportion of mostly young people had already had Covid but barely noticed.

As the number of deaths remained the same this reduced mortality rates to X per 10,000.

Not an epidemiologist or nothing but it struck me as significant at the time.

Last edited 3 years ago by karenovirus
2
0
Davke
Davke
3 years ago

Can we now just accept that the ” vaccines ”
Do not stop transmission. Do not stop infection. Offer very limited mitigation of symptoms and are, for want of a better word, Pish!

Last edited 3 years ago by Davke
37
-1
helenf
helenf
3 years ago
Reply to  Davke

Worse than that. If being “vaccinated” makes you more likely to test positive for covid than being unvaccinated (if you’re over 30), and vaccination offers no significant protection from death with covid in the over 60’s, doesn’t that mean that you are more likely to die “with covid” if you are over 60 and vaccinated (v unvaccinated)?

3
-1
karenovirus
karenovirus
3 years ago

Something is affecting bozo,
Here he has a half minute Biden moment.

The Guardian YouTube slags him off for talking about Pepa Pig but of more interest is the first thirty seconds.when he loses his place in his speech, cannot ad lib and repeats himself.
Bullingdon boys are supposed to be good at recovering from lapses like this.

20211122_154054.jpg
Last edited 3 years ago by karenovirus
19
0
steve_z
steve_z
3 years ago
Reply to  karenovirus

spike proteins backing up in his brain?

14
0
karenovirus
karenovirus
3 years ago
Reply to  steve_z

Sorry about the Guardian link, most others edit out those very illuminating first thirty seconds.

Last edited 3 years ago by karenovirus
4
0
cornubian
cornubian
3 years ago
Reply to  steve_z

You really think he had the full monty?

5
0
steve_z
steve_z
3 years ago
Reply to  cornubian

probably. I think they actually believe it works. boris had covid and now 2 jabs and a booster. he’s probably addicted to spike proteins

8
0
miketa1957
miketa1957
3 years ago
Reply to  steve_z

I really believe they all have had it. I don’t believe the saline-jab theory. The point is, these people are true believers in the vaccine, and for a true believer to have a saline-jab, would be to betray thrie faith.

3
-2
Julian
Julian
3 years ago
Reply to  miketa1957

I think some believe up to a point, but probably they figured it was best to have it to avoid anyone discovering that they had cheated, which would be politically disastrous

6
0
TheBluePill
TheBluePill
3 years ago
Reply to  Julian

The truth is probably above their pay grades. If you were a super-villian like Gates, would you trust the truth to a bumbling bafoon like Bozo?

7
0
karenovirus
karenovirus
3 years ago
Reply to  TheBluePill

Bumbling bafoon in this clip certainly.

2
0
Julian
Julian
3 years ago
Reply to  karenovirus

He’s certainly not oozing confidence these days but I think he’s far from a buffoon. It’s an act.

5
0
TheBluePill
TheBluePill
3 years ago
Reply to  Julian

I don’t think it is an act. He is a corrupt P.O.S. psychopath who would probably sell his kids’ kidneys if it meant he could keep nut nuts happy with some new designer wallpaper. A conniving bafoon perhaps.

12
0
Julian
Julian
3 years ago
Reply to  TheBluePill

Corrupt, POS, psychopath – I would not disagree

I don’t think you can get to be PM if you’re stupid.

4
0
TheBluePill
TheBluePill
3 years ago
Reply to  Julian

Political parties can get any malleable turd into a safe seat.

2
0
Davke
Davke
3 years ago
Reply to  karenovirus

Very normal behaviour in a functioning alcoholic!

10
0
Jon Garvey
Jon Garvey
3 years ago

The evidence from Taquet and colleagues’ paper could therefore be taken as supporting voluntary boosters for high-risk group.

That doesn’t seem to follow where the risk is being over 60. If initial vaccination does not prevent death, why would a third be expected to do so?

7
0
Clarisse
Clarisse
3 years ago

Soo, how did they find out that the individuels in the tested group had Covid, only with a Pcr Test ? Hopefully not, that would make the study completely useless.

6
0
A Y M
A Y M
3 years ago

“ those who had been vaccinated at least 14 days prior to infection”
Get back to me on the stats for death within 14 days of injection….
Also, let’s get the data on cancer diagnosis for jabbed and non jabbed.
TIA

Last edited 3 years ago by A Y M
10
0
RickH
RickH
3 years ago

It seems that even amongst the sceptical, there needs to be a constant reminder that SARS-CoV-2 really is no big deal – even for the ‘vulnerable’ groups. The increased mortality in the older spectrum largely reflects increased mortality from anything :

image_2021-11-22_160826.png
Last edited 3 years ago by RickH
13
0
steve_z
steve_z
3 years ago
Reply to  RickH

and Sweden showed zero excess mortality. its just old people dying of old age and this entire panic is being driven by people writing the name of a novel coronavirus on the death certificate instead of writing ‘old age’

of course they will find younger people that died and go on about them. I had a friend die of a heart attack in his 30s. and another died of sepsis at 40. shit happens but this is not a pandemic of note

look at Sweden – no lockdown, no masks and no bloody deaths!

its all bullshit

13
0
miketa1957
miketa1957
3 years ago
Reply to  RickH

Yes, the zero-to-small excess mortality (depending on country) is the give away. Absentia Covid, the people who dies of Covid would have died of something else.

6
0
TheGreenAcres
TheGreenAcres
3 years ago

No vaccine protects against infection itself. What they do is enable the body to combat the virus once infected, so that you don’t develop the disease or it’s symptoms.

The question for me is; how effective are the vaccines at protecting against developing symptoms of the disease vs naturally acquired immunity?

1
0
steve_z
steve_z
3 years ago
Reply to  TheGreenAcres

I find it fascinating how amazing the immune system is. it can literally fight off anything but chooses not to because there are evolutionarily other things of importance (getting food, finding a mate). so it dials it down to the minimum to conserve energy (something we have in abundance) and sometimes gets wrong footed.

1
0
RW
RW
3 years ago
Reply to  TheGreenAcres

I’ve posted this a couple of times myself. Pfizer also never demonstrated that the vaccine supposedly prevented infection, only that it supposedly prevented mild cases of COVID-19 and not asymptomatic cases of PCR-positivitis. Efficiency against infection is just another propaganda lie from the Covid forever for all the others! camp.

5
0
TheyLiveAndWeLockdown
TheyLiveAndWeLockdown
3 years ago
Reply to  RW

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8546144/

and the jabs have effects…

our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.

as does lockdown

https://metro.co.uk/2020/07/20/coronavirus-lockdown-cause-200000-extra-deaths-13014848/

Coronavirus lockdown could cause ‘200,000 extra deaths’

5
0
TheyLiveAndWeLockdown
TheyLiveAndWeLockdown
3 years ago
Reply to  TheyLiveAndWeLockdown

https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.10712

Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test

3
0
cornubian
cornubian
3 years ago

Any study that begins by saying “Vaccination has proven effective against infection with SARS-CoV-2, as well as death and hospitalisation following COVID-19 illness” cannot be trusted. We already know the absolute efficacy is close to zero and during the ‘trial’ more people died in the ‘vaxed’ group than in the placebo group. So we dont meed any more number fiddling thank you.

20
-2
Vxi7
Vxi7
3 years ago
Reply to  cornubian

As last year people were locked down in the ‘peaks’ now they can act like that the vaccines are working. As there is almost 0 control group left you will never be able to prove otherwise.

0
0
thinkcriticall
thinkcriticall
3 years ago

Anyone that’s studied the medical literature, particularly the Pfizer study is aware that these jabs have NO efficacy and a horrendous safety profile. Slowly but surely the facts are becoming undeniable. It is becoming patently obvious with every passing day and the news from Europe, that this is fundamentally about one thing; Control of the ‘Useless eaters’. There is no Science anymore only politics. If we halt this. Which we must. We must forever be vigilant. We became complacent while the enemy infiltrated all our institutions and slowly erroded the Christian values that this country is based upon. Hold the line. We will succeed!

16
0
MTF
MTF
3 years ago

The 95% confidence intervals for >65 are very large. This means the difference is statistically insignificant but it could be quite big. Also it is curious that the mean difference between vaccine and unvaccine in >65 seems to get larger as the time after vaccination gets greater.

Last edited 3 years ago by MTF
0
-4
GlassHalfFull
GlassHalfFull
3 years ago

The virus is yesterdays news.
The pandemic now is the injuries and deaths caused directly by the experimental jab, but will be blamed on Covid, which will become worse with each so-called booster.

10
0
BS665
BS665
3 years ago

Just as well since most are brain dead already…

3
0
LonePatriot
LonePatriot
3 years ago

They test for the flu since they’ve never isolated Covid-19. Which makes me wonder how they can tell there is a delta variant. They never isolated the virus but they use a test to show the damage of a solution does on monkey kidney cells then show the cellular debris as proof of the virus. So, they can use this method to claim an UNENDING! amount of variants. A lot of cancers and “viruses” are probably just different forms of parasites. Since the tests can’t differentiate between cold and flu and covid then doesn’t that mean ivermectin cures both the cold and the flu? Welcome to “they’ve been lying to us our entire lives about everything”. Get your Ivermectin while you still can! https://ivmpharmacy.com

0
0
Anti_socialist
Anti_socialist
3 years ago

Just say it, the mRNA toxic chemical cocktail is a dud.

2
0
godders
godders
3 years ago

“To the extent that the vaccine protects against infection, it will protect against serious illness and death too”.

What the heck does this even mean?

The vaccine doesn’t stop transmission, so it won’t stop you getting infected with the Kung Flu or passing it on.

Let’s all stop tap-dancing around the pseudo-vaccines ponzi scheme and call it out for what it is – the greatest medical scam in history.

Last edited 3 years ago by godders
6
0
cloudster
cloudster
3 years ago

Why even the argument for over 60s. It was never meant to and never have been proven to protect anyone from anything. On the contrary it has been designed to do harm.

0
0
Liewe
Liewe
3 years ago

“This inclusion criterion thus excludes patients with obvious vaccine hesitancy (so-called ‘anti-vaxxers’) as this is correlated with other health-related behaviours that might confound associations with COVID-19 outcomes”

Which people < 60 don’t get the annual Flu vaccine? I would wager the healthiest ones who don’t see Flu as a problem. Since when has skipping the Flu vaccine become an anti-vax position?

This study could also say: having the Flu jab increases your chance of death from Covid in the < 60’s.

1
0
Infinite Ecologist
Infinite Ecologist
3 years ago

Could the declining vitamin D status of the elderly be playing a part here? Among the elderly, might this not be a relevant critical component in their immune response capacity?

3
0
nt
nt
3 years ago

Hi there, I just wanted to comment that I do not agree with what you have said a few times recently and having coined the expression ‘healthy vaccine effect’ I would say it’s the opposite from personal experience, as an extremely healthy 55 year old nutritional therapist who has decided not to take the jab: i am on no medication, I eat very well, i am a good weight, i look after myself etc etc there are many many like me who decided to trust in our immune systems being able to cope rather than taking an unknown, experimental vaccine. I am not an anti Vaxxer just never felt the need to have flu jabs ( never had flu) and although I had COVID it was very mild, after an antibody test I see I am still naturally protected after a year, thus this offers better protection than the vaccine which wanes after 6 months supposedly…I believe in the power of good food, and relevant supplements like vitamin c, d, zinc etc. So although there may be some who cannot take the vaccine as they may have an underlying condition – especially an autoimmune disease which the vaccine may make worse – or they may have had an adverse reaction to the first jab and decided not to continue…I think there are many like me who do not rely on a a’ magic bullet’ to solve this crisis but prefer to see it out naturally…also I think I am actually quite sensible and risk averse – just not fear averse! in good health to you all…

3
0

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