We’re publishing today a piece by John Collis, a recently retired nurse practitioner, in which he uses the work of Professor Daniel M. Davis to explore the role of genes in the immune system and asks whether genetic diversity between individuals and groups might explain why some people are worse affected by Covid than others. Here’s the introduction:
Why are different people affected differently by a SARS-CoV-2 infection? Through this article, based on The Compatibility Gene by Professor Daniel M. Davis, I hope to be able to provide some insight. While this is a very complex subject, with the understanding of the different components and their interactions having developed over the past 60 years or so, I will set it out as clearly as I can. To simplify matters I do not discuss here the role of cytokines or other chemical signalling between cells.
The immune system is built around the body’s ability to distinguish between components that belong there (self) and those that don’t (non-self). Pathogens such as bacteria, protozoa and parasites have very different DNA and are relatively easy to identify as non-self. Viruses are different: how does the immune system distinguish between a healthy ‘self’ cell and an infected ‘self’ cell?
The part of the immune system that is responsible for this are T-cells. T-cell production is controlled by the Thymus gland located in the chest, between the lungs. Significantly, this gland is large in children, starts to shrink post puberty and is very small in older adults. Could this explain why children are less susceptible to the effects of SARS-CoV-2 infection? Could the changes in the thymus gland explain the effects being seen in teenagers and young adults? Are some of these adverse events immune system mediated?
Worth reading in full.
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Answer: no, as there is no such thing as Covid-19. Now, could particular genotypes be more susceptible to pneumonia ? Aside, pneumonia is what you get when you go to the hospital.
Certain genotypes are more susceptible to influenza. There is also community acquired pneumonia.
… especially in the community known as the hospital. Pneumonia is real. Probably the main reason for excess mortality of 2020-21 repackaged as ‘Covid.’ But I submit that there are no contagious diseases, only shared habits and/or shared environments that contribute to simultaneous illness. I am convinced that this is the case and suggest it is a welcome improvement over the toxic notion of others as disease vectors … against which there are no truly effective arguments against curbs on freedoms, especially in this bold new world of radical Safetyism.
When I say community acquired it is literally that, not hospital acquired. What you’re alluding to is the terrain theory of disease. I would argue that pneumonia wasn’t the prime cause of excess mortality in early 2020 as the coding for patients with pneumonia and other respiratory diseases fell below the SARS-CoV-2 curve and also the excess mortality curve.
Much to be said in response, but the excess mortality of 2020 can be readily attributed to the effects of panic and despair, no virus needed.
I’m not arguing with that, the excess mortality curve occurs at the minimum of the respiratory admissions, if it were at the peak of admissions then it could be argued that respiratory issues were the cause. There were clearly alternative causes, which just happened to coincide with a positive test. Don’t forget then there was no time limit between a positive result and death occurring when it would count asa Covid death, irrespective of the real cause of death.
Spot on John, as per my comment above this is simply a topic the .gov wishes to avoid, like obesity
There is essentially no such thing as COVID in the ‘fit and healthy’
Genes linked to severe Covid-19 risk identified | The University of Edinburgh
I thought there was a patent for Covid 19
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Oh yes, the vaccines are years-old recipes. Of course there is nothing to vaccinate for.
Oh dear.
Dale is another David Icke nutter.
Covidian responds “Icke! Lanka!”
I rest my case.
Dale is also a Lanka Wanka.
Last I checked Icke was a Branch Covidian like HeadHalfFull
John Collis has gone to the trouble of writing a detailed serious piece for The Daily Sceptic and you go and spoil it with your “There is no such thing as Covid-19”.
I expect John to recover in fine style, follow up on trends in unicorn sightings.
Don’t worry about me, my discussion still stands for other disease processes. I wanted to provoke debate, hence the questions posed in the piece. If someone doesn’t believe that CoViD19 exists, that’s fine by me, people have become ill and have died from something, whether that be pneumonia or some other respiratory condition caused by an infection.
Dr Sam Bailey is sceptical about the existence of SARS-CoV-2 or other viruses as she is an advocate for terrain theory rather than germ theory, does that mean she should be ignored? Of course not.
It is essential that people are allowed to express alternative views, otherwise dogma develops and dissent is actively discouraged, as has happened on YouTube, Facebook and other platforms.
“does that mean she should be ignored?”
Not at first but her argument needs to be assessed for veracity like every one else.
I have seen her videos and read extracts from her book and she is talking absolute rubbish just to sell her book (always on display) to the gullible.
It appears to be more profitable to be a quack than a real doctor these days as shown by her co-author Tom Cowan an ex doctor who had to hand in his license due to malpractice.
https://www.acsh.org/news/2021/02/10/how-quacks-become-millionaires-5g-covid-doctor-will-sell-supplements-15336
Many of her claims are not supported by evidence and have been totally debunked by real scientists who have shown real evidence to debunk her claims.
She used to be a TV doctor from New Zealand who appears to have little understanding of modern virology.
Her wild claims have been debunked on this science website ……
https://blog.waikato.ac.nz/bioblog/2021/04/sam-bailey-on-isolating-viruses-and-why-she-is-wrong/
She has also been debunked here ……
https://integralworld.net/visser214.html
So yes she should NOW most definitely be ignored.
Dale you are a loon / .gov social media staff, DailySceptic staff please deal with this
But good article DS, it’s well established that sepsis is genetic, it’s prob fair to say there is no essentially no such thing as a ‘fit and healthy’ person who suffers severe COVID
From the BBC pretending obesity isn’t real to .gov pretending natural immunity isn’t real the science of the pandemic has been poor if not just poltical
We even know the genes in question now:
Genes linked to severe Covid-19 risk identified | The University of Edinburgh
Don’t give them another scholastic variable!!😝🤑😭
Controlled media, mass gullibility, culture (with food) and climate (vit. D) may also be variables. Mr Ivor Cummins gave a quick explanation 18 months ago referencing the Edgar Hope-Simpson’s work.
Bear in mind that these genes vary across geographical populations, with definite boundaries between these differences, some alleles predominate in some areas whereas other alleles predominate in other areas.
Culture and climate could be epigenetic influences.
I understand and appreciate Ivor’s early efforts to inject sanity. But he is a Hope-Simpson junkie.
Highly relevant to the proposition, of which Will Jones was one of the first exponents, that new variants surge, peak and then die back as they spread among the part of the population most susceptible to them, and this will happen regardless of NPIs. The article above gives some genetic flesh to the idea.
Just to clarify this applies to all viruses, not just SARS-CoV-2.
Could this explain the many anecdotal reports of whole families being infected, but in some cases many members die, yet others where every member has the mildest of symptoms?
I wonder if these instances were collected and plotted for proportion that died, would we get a normal distribution, or seperate seals at either end?
Nice write up by the way
Anyone working with a group of people knows that it is the same few who get colds and suffer badly with them again and again. The rest can go many years without. It is not a division between young and old, diet, There are obvious differences in immune systems.
And the reason for these differences? Our genes.
My Wranglers must be quite effective. Two years in, no vax, mask, tests or social distancing and I’m still here.
There must be a graph for this somewhere?
Your genes determine everything!….Even your capacity for critical thought, which as we will find out in the months and years to come, will turn out to be the most important!
No one knows.
Which is a shame but there’s been no big money in immunology for at least 25 years due to the rapid expansion (fast bucks to be made) of gene tec..
Which is an even bigger shame because it means the modern “vaccine “experts” know the square root of F. all about the effects their gene therapy “vaccines” have upon both the innate and adaptive immune systems.
Very little is known of precisely how, particularly the innate system ( 95% of the whole) works and particularly the synergy of both systems
They are messing around with things they do not, and cannot, understand.
Even I could name half a dozen fundamental unknowns re the immune system in a heartbeat. But it’s the unknown unknowns which are the worry.
“The compatibility gene” is about 9 years old, but anyone interested in immunology should read his later book “The Beautiful Cure”. This is about 3 years old and in my view gives a more complete and better understanding of the current knowledge regarding immunity. It too though is inevitably littered with “unknowns”. Each answered problem in itself leads to ten more!
So, here we are.
A worldwide “pandemic” Lol, and we are busy vaxxing the whole bloody planet with dodgy jabs, effects unknown.
This is pure evil idiocy.
GVB and others knew this and warned us from the outset, but were and are deliberately ignored.
And I’m a selfish idiot Mr. Blair….
Having said that there are many knowns about immunity, for example diet, vit d status, exercise, sleep quality, metabolic health, connectedness and social isolation even fresh air and the government trashed its way through almost all of those with its policies on masks, lockdowns, social distancing and isolation.
A persons genetic makeup is the starting point, other influences as Milo has suggested have an impact. Vitamin D deficiency is well known for darker skinned individuals, particularly in people from India, the Caribbean, Africa or similar due to the sunlight significantly varying across the year, whereas in tropical and other lower latitudes it varies little. These would be epigenetic variables which can alter the trajectory of health in two otherwise identical people. Tim Spector does a lot of his research looking at the differences between twins.
Why aren’t you our health minister? 💕💕
As opposed to Bliar, who is a selfish, lying piece of shit. Other expletives are available
I have read both books, I actually read the later book first, but with references to the earlier tome I needed to read it as well. It was just that there were parts of the earlier text that resonated with the current situation. I need to revisit the second book. I have also been watching presentations on virology by Vincent Racianello on YouTube.
Why not. Look at the Black Death some people had a natural immunity and survived although almost certainly exposed to the same plague rats as those who died (in large numbers). A 1/3rd to 1/2 of the population died so a good percentage survived.
When TB jabs were given out a school, we were tested to see if you had natural immunity. If you were naturally immune there was no need for the jab. (I’m not an anti vaxxer, anti bullying, anti coercion, anti lying for a medication that is not a vaccine but sold as a vaccine).
or exposed to the plague gerbils
A number of years ago Scientific American carried a piece about the Black Death and those surviving passing on their genes, and suggesting that most of us alive today carry a genotype more resistant to the plague.
I’ve still no idea if I’ve had COVID.
I’d like Omicron please … to get it over now, not when when I’m 75 or 85 and it might be worse.
But I think I’ve identified this as the disease I had in late summer 1977 … it was so bad that I needed 5 days’ bed rest
https://en.wikipedia.org/wiki/1977_Russian_flu
COVID-19 caused by a SARS-Cov-2 infection, I suppose you mean. Quite recently, I shelled out for a proper independent test to see if I had been, or not. This was done via blood sample assessment to see if I have a batch of T-cells related to the virus mentioned, and it appears that there aren’t any, so it’s unlikely that it ever occurred. A cynic might say that it was a waste of money, but if it was the other way round, it could have been a good investment.
Of course, there are plenty of other things we can do to encourage our immune system to work well. Might also be worth playing with this: https://qcovid.org/Calculation to work out the risks for various people, including yourself.
Dr. Vladimir Zelenko said anyone that willfully vilified and obstructed access to hydroxychloroquine and ivermectin in the prevention and treatment of Covid-19 is guilty of first degree capital murder, genocide, and crimes against humanity. They are trying to jab as many people as possible so that their great reset aka depopulation plan work. I believe in God & Jesus. If I get sick I will take my Ivermectin that I stashed just in case and leave rest to God. If you want to get Ivermectin you can visit https://ivmpharmacy.com
Apart from the genetics determining whether you can resist a coronavirus infection as laid out here, genetics also determine whether that infection will trigger an immune over-reactivity, or cytokine storm. There are several identified chromosomal differences that predispose to this – and not just with SARS-CoV-2 but with other coronaviruses and indeed other trigger factors. The evidence is laid out in the textbook on cytokine storm syndrome by Cron and Behrens, which pre-dates the current coronavirus epidemic. It really is time for any serious commentator to read this (where you will find, among other things, that the treatment includes steroids and tocilizumab, not to mention another interleukin antagonist, anakinra). Most of the so-called mysteries of Covid-19 have been outlined, in some cases many years ago.
There’s no such thing as Covid-19? oh yes there is. But it’s a very specific condition, which commentators and scientists have successfully conflated by loose terminology. You get infected with SARS-CoV-2. This may be asymptomatic, or produce a cold or flu-like illness. If, however, your immune system goes into overdrive, with the release of numerous inflammatory mediators, you develop severe lung disease in which the lining cells of the alveoli leak and cannot properly absorb oxygen, blood clotting, cardiac and renal inflammation. This constellation of symptoms is called Covid-19 – although as I have said exactly the same thing happens in other coronavirus and non-coronavirus conditions and has been known for years to be commoner in some ethnic groups because of genetic differences.
Getting SARS-CoV-2 infection may have social or economic causes (eg poverty, overcrowding, multiple occupancy of dwellings etc). Getting Covid-19 as a consequence depends on how sensitive your immune system is to being triggered into overdrive – which is genetic.
See my (now rather extensive) blog at https://bamjiinrye.wordpress.com for more details.
For me the compatibility genes form the baseline of an individual’s immune system response. What happens subsequently is affected by an individual’s environment. Instead of nature v nurture it’s more a case of nature + nurture.
The answer is yes. It’s called the immune system.