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Stanford Study Finds Vaccine mRNA and Spike Protein Persist in the Body for Months Following Vaccination – But Not Following Infection

by Will Jones
18 March 2022 1:38 PM

A study from Stanford University, published in Cell, has found that vaccine mRNA and spike protein persist in lymph nodes for up to two months following the second vaccine dose. This is in contrast to what happens following infection, where spike protein was found only rarely.

In contrast to disrupted germinal centres in lymph nodes during infection, mRNA vaccination stimulates robust germinal centres containing vaccine mRNA and spike antigen up to eight weeks postvaccination in some cases…

The observed extended presence of vaccine mRNA and spike protein in vaccinee lymph node germinal centres for up to two months after vaccination was in contrast to rare foci of viral spike protein in COVID-19 patient lymph nodes… COVID-19 patient lymph nodes showed lower quantities of spike antigen.

The researchers also found the concentration of spike protein in the blood following vaccination was similar to that during infection.

At least some portion of spike antigen generated after administration of BNT162b2 becomes distributed into the blood. We detected spike antigen in 96% of vaccinees in plasma collected one to two days after the prime injection, with antigen levels reaching as high as 174 pg/mL. The range of spike antigen concentrations in the blood of vaccinees at this early time point largely overlaps with the range of spike antigen concentrations reported in plasma in a study of acute infection, although a small number of infected individuals had higher concentrations in the ng/mL range. At later time points after vaccination, the concentrations of spike antigen in blood quickly decrease although spike is still detectable in plasma in 63% of vaccinees one week after the first dose. 

The researchers found evidence of ‘original antigenic sin’ from the vaccines, where a person vaccinated and then infected with a variant develops a weaker antibody response to that variant than an unvaccinated person infected with the variant. They describe it as a “strong imprinting effect of prior vaccination”.

We find that prior vaccination with Wuhan-Hu-1-like antigens followed by infection with Alpha or Delta variants gives rise to plasma antibody responses with apparent Wuhan-Hu-1-specific imprinting manifesting as relatively decreased responses to the variant virus epitopes, compared with unvaccinated patients infected with those variant viruses…

The extent to which vaccine boosting or infection with different variants will effectively elicit antibody responses to new epitopes or rather increase responses to the epitopes of antigens encountered previously, as in the ‘original antigenic sin’ phenomenon described for influenza virus infection and vaccination, will be an important topic of ongoing study.

The researchers confirmed the fast decline of antibodies following vaccination, finding a 20-fold drop after nine months.

Our data demonstrate that vaccinee plasma and saliva spike and receptor-binding domain-specific IgG concentrations decrease from their peak values by approximately 20-fold by nine months after primary vaccination but quickly exceed prior peak concentrations in seven to eight days after boosting with a third vaccine dose.

The study also confirms that vaccination doesn’t generate IgA antibodies (found especially in the respiratory and digestive tracts and mounting a first defence against infection) or IgM antibodies (found especially in the blood and lymph fluid), but only IgG antibodies (found in the blood). This has been proposed as a reason that vaccination is so poor at preventing infection and transmission.

Surprisingly, perhaps, the researchers found that vaccination (whether mRNA, adenoviral or inactivated virus) stimulated a broader antibody (IgG) response than infection, leading them to predict that “antibodies derived from infection may provide somewhat decreased protection against virus variants compared with comparable concentrations of antibodies stimulated by vaccination”.

However, the post-infection IgG antibody response improved over several weeks.

Over time, infected patient plasma samples showed improvement in variant receptor-binding domain binding relative to Wuhan-Hu-1 receptor-binding domain, suggesting evolution of the antibody response through at least seven weeks post-onset of symptoms.

In addition, the apparent breadth-benefit of vaccination over infection disappeared when “whole spike antigens” were tested rather than just the receptor-binding domain targeted by the vaccine, suggesting the benefit may be an artefact of the study design not found in a real encounter with the virus.

Notably, the increased breadth of vaccinee IgG compared with COVID-19 patient IgG binding to viral variant antigens was greatest for receptor-binding domain, the main target of neutralising antibodies, and was decreased or not detected when whole spike antigens were tested.

Other limitations mentioned include not looking at “antibodies binding to the spike N-terminal domain” or other antibodies: “Our data do not reflect potentially functional antibodies binding to the spike N-terminal domain, or antibodies that may have other activities in vivo.”

The study also didn’t look at T cell responses, among other things:

Further mechanistic investigations into the differences in antibody breadth elicited by vaccination and infection are needed to define the roles of T cell help, antibody affinity maturation, germinal centre function, and innate immune responses to vaccine components, as well as the cellular and subcellular distribution of vaccine RNA and expressed antigen in lymphoid tissues.

The high concentration in the blood of spike protein following vaccination and its persistence along with vaccine mRNA in lymph nodes for months, in contrast to the situation post-infection where such persistence is rare, will fuel concerns about the safety of these Covid vaccines. It has been argued that the spike protein is itself pathogenic, not inert, and that the free spike proteins generated by the vaccines have greater capacity to bind to more types of cells than the virus particles themselves, and that this may be what lies behind many of the serious adverse events reported to regulatory bodies and identified in case reports. This warrants further investigation.

Tags: mRNA vaccinesSafetySide-effectsSpike proteinStanfordVaccine efficacyVaccines

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37 Comments
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itoldyouiwasill
itoldyouiwasill
3 years ago

We are seeing the slow de-stigmatisation of terms which, the mere mention of in public, would have ended careers this time last year. First to fall were herd immunity then natural immunity. Now we have the acceptance of original antigenic sin. Maybe Ivermectin will fall next!
The next challenge is to be very precise in identifying which dark, monovalent forces have spent the past 2 years trolling the internet and social media to make these phrases so unacceptable. We all know these things don’t happen by accident. Who would have most to gain by censoring debate in this way?

120
0
Marcus Aurelius knew
Marcus Aurelius knew
3 years ago
Reply to  itoldyouiwasill

Billy Goates

43
0
Doom Slayer
Doom Slayer
3 years ago
Reply to  itoldyouiwasill

Ivermectin Has Fallen!

Gerard Butler returns as Mike Banning. After watching his wife die cos clown doctors wouldnt give her Ivermectin, Banning goes deep underground and enlists the help of Malone, McCullough, Rogan and Brand to bring down the big state once and for all. In the shady world of gutter science they uncover unbelievable papers and documents known in the underworld as evidence. Can they prove that the science isnt settled?

Tickets available now for a box of horse dewormer.

Last edited 3 years ago by Doom Slayer
43
0
steve_z
steve_z
3 years ago

“The researchers found evidence of ‘original antigenic sin’ from the vaccines, where a person vaccinated and then infected with a variant develops a weaker antibody response to that variant than an unvaccinated person infected with the variant. “

“Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)).[1] Unfortunately, this vaccine induced a phenomenon that came to be known as vaccine-associated enhanced respiratory disease (VAERD), in which children who had not previously been exposed to RSV and were subsequently vaccinated would develop a severe form of RSV disease if exposed to the virus itself, including fever, wheezing, and bronchopneumonia.[1] Some eighty percent of such children (vs. 5% of virus-exposed controls) were hospitalized, and two children died of lethal lung inflammatory response during the first natural RSV infection after vaccination of RSV-naive infants.[1] This disaster hindered vaccine development for many years to come”

I think I’m still at the ‘wait and see’ stage with regard to getting vaccinated!

44
0
Rowan
Rowan
3 years ago
Reply to  steve_z

Hard to see why you haven’t yet made up your mind.

17
0
steve_z
steve_z
3 years ago
Reply to  Rowan

me waiting to make up my mind

comment image

30
0
Rowan
Rowan
3 years ago
Reply to  steve_z

Funny enough, though for me, it pushes the pro-vax agenda.

4
0
John Dee
John Dee
3 years ago
Reply to  steve_z

At least you weren’t one of those who gained too much weight during the lockdowns.

18
0
sophie123
sophie123
3 years ago

There’s a very nice explanation of what the spike protein is, where it goes and how long it hangs around on the “Science with Dr Doug” podcast (on Spotify).

11
0
swedenborg
swedenborg
3 years ago
Reply to  sophie123

https://anchor.fm/ScienceWithDrDoug

5
-1
Milo
Milo
3 years ago
Reply to  sophie123

And see also this from Steve Kirsch

Things you should know about the new Pfizer documents (substack.com)

Here are the some of the issues we will cover in this review. More to come as we learn more:

  1. Pfizer claimed repeatedly in their documents to the FDA that their vaccine would “prevent” COVID-19.
  2. Pfizer knew the injection’s adverse effects would increase with more injections of continuing boosters.
  3. Pfizer knew their injections did not stay at the injection site.
  4. Pfizer knew that the vaccinated group reported far more systemic adverse events than the placebo group.
  5. Pfizer knew that the efficacy of the vaccine waned very quickly over time; by as much as 50% in as little as 1 month after the second dose. How come we weren’t warned about that???
  6. Pfizer defended VAERS (because they didn’t want extra reporting cost burdens).
  7. There are six individuals that signed up for two different clinical trials at two different sites which is really odd.
  8. Pfizer knew vaccinated individuals could still catch COVID-19 and test positive.
  9. There are 1,448 pages comprising 9,704 individual subjects who were excluded from the trials. There isn’t enough detail to know why.
  10. Pfizer paid $2,875,842.00 for their application to the FDA. This is more of a point of information for now.
  11. It is troubling that Pfizer redacts information that is not proprietary that would be very helpful in assessing the data such as the number of doses administered in the ADVERSE EVENTS OF SPECIAL INTEREST” (AESI) document (aka the 5.3.6 document).
  12. Pfizer only tests you for COVID if you have at least one symptom. If the vaccine suppresses symptoms (which it apparently does), then it will falsely appear as if the vaccine reduces the number of COVID cases.
  13. How could anaphylaxis not show up in the Phase 3 trial on any of the 44,000 patients, yet show up as a major safety concern in the post-marketing document?!?

AND see also this

Whilst you’ve been distracted by Russia-Ukraine, the UK Government quietly published data confirming the Triple Vaccinated are just weeks away from developing Acquired Immunodeficiency Syndrome – The Expose (dailyexpose.uk)

The latest official figures from the UK Health Security Agency show that triple vaccinated people aged 30-70 have now lost at least 70% of their immune system capability compared to the natural immune system of unvaccinated people.
Their immune systems are deteriorating between 10 and 30% per week on average, with the deterioration much larger and quicker among the younger age groups.
If this continues at the current rate then all triple vaccinated 18 to 39-year-olds will have 100% immune system degradation by the middle of April 2022, with all other triple vaccinated age-groups following suit not long after.
In other words, official UK Government data strongly suggests the triple vaccinated population are rapidly developing acquired immunodeficiency syndrome.

23
-2
Susan
Susan
3 years ago
Reply to  Milo

While the shot-up x3 are destroying their immune systems, they continue to lord it over us. I get emailed every week requests to renew membership at The Met, Pierpoint Morgan etc. museums, but these once great, now ridiculous institutions bar my entry because I have taken the rational decision to protect my health.
Will they be the authors of their own demise?

15
0
Freecumbria
Freecumbria
3 years ago

Dr Mobeen covered part of this study yesterday in this excellent video

Spike Protein Gets In The Blood of Vaccinated Individuals (Firm Data From A Stanford Study)

https://www.youtube.com/watch?v=-Y7dTMzn9B8

He’s intending covering some other aspects of the study in later videos

Last edited 3 years ago by Freecumbria
14
0
amanuensis
amanuensis
3 years ago

Nice to see this research being done. Shame that it was done after vaccinating the world, not before.

There are two problems with the longer term persistence of spike protein:

  • As mentioned in the text, there is evidence that the spike protein itself is pathogenic, and thus you’d expect to have some persistence in side-effects generated by the spike protein. If there’s evidence that it is present for 8 weeks then studies should look for side effects for 8 weeks — most studies stop looking after 3-4 weeks. What’s more, if the studies use a self control methodology (looking at you, Julia Hippisley-Cox) then you’d expect a significant under-estimation of side-effect rates.
  • But there is another problem — if the immune system is presented with long term exposure to a specific antigen then there is a chance of immune-tolerance developing, ie, that the immune system treats the antigen (ie spike protein in this case) as ‘self’ and thus no longer responds to it. This would have the result of any infection with a pathogen expressing that antigen (ie, Covid in this case) having lower symptoms (as they’re generally related to the immune response, not the virus itself) and lower risk of serious-complication and death from the virus (as Covid deaths result from an immune over-reaction, the ‘cytokine storm’). But, it would also have the effect of increasing the risk of infection, prolonged infection once infected, and complications resulting from the viral infection itself, which are thought to include clotting related disorders (such as stroke, thrombosis, embolism, haemorrhage), heart related disorders (myocarditis, pericarditis) and neural problems (GBS etc). Whether this problem (immune tolerance) exists and whether the infection complication rate exceeds the rate of problems seen in an unvaccinated population is yet to be determined.

I’d note that in the case of immune tolerance, it might be that 2 months ‘isn’t enough’ — but we’re giving repeated vaccinations at 3 month intervals, which would lead to a consistently high level of spike and spike production in the lymphatic system (according to the OP’s paper) over many months, which is certainly getting into ‘worry’ territory.

The potential for OAS is just the icing on the cake.

Last edited 3 years ago by amanuensis
60
0
sophie123
sophie123
3 years ago
Reply to  amanuensis

I agree with all of this. Nothing more to add. The mass and repeated administration of these biological agents is nothing short of catastrophic folly.

I’m going to be looking closely at companies working on development of drugs tackling misfolded proteins….seems like it could be a good investment.

35
0
Milo
Milo
3 years ago
Reply to  sophie123

do you mean as a kind of antidote to the damage done by the jabs?

3
0
BurlingtonBertie
BurlingtonBertie
3 years ago
Reply to  sophie123

Dr Kat Lindley, one of the medics who set up the World Council for Health, has developed a bioweapon injection detox plan with which she has had a lot if success.
Home | Katlindleydo

0
0
John Dee
John Dee
3 years ago
Reply to  amanuensis

Shame that it was done after vaccinating the world, not before.

Indeed. I can remember as far back as when injections were tested for safety before being shot into the arms (and elsewhere) of populations.
Of course, if you’re a shabby pharma company, you’d rather be able to jab first, make your profits and relax, since those nice government folk gave you a ‘stay out of jail’ card should there prove to be any unfortunate outcomes from receipt of your elixir.

23
0
Catee
Catee
3 years ago
Reply to  John Dee

A ‘get out of jail free’ card indeed, which will become void if it is found that they falsified efficacy data and/or adverse reaction data. There’s good reason pfizer tried to bury their papers for 75 years.

16
0
TheGreenGoblin
TheGreenGoblin
3 years ago
Reply to  Catee

Yet why did the FDA fight so hard for the same?

7
0
Judy Watson
Judy Watson
3 years ago
Reply to  TheGreenGoblin

Fauci and others of his ilk

2
0
mishmash
mishmash
3 years ago
Reply to  amanuensis

Clotting and heart-related problems caused by the fake vaccines dwarf any claimed to be caused by covid.

1
0
civilliberties
civilliberties
3 years ago

yes,

not exactly the surprise of the century, wasn’t mike yeadon saying this a yr ago?

36
0
BeBopRockSteady
BeBopRockSteady
3 years ago
Reply to  civilliberties

The Salk Institute published a paper around March 21 which pointed towards this pathogenicity of the spike. They were quickly admonished to update their paper with a statement to say it was OK, the spike from vaccination was different from infection. Or something to that effect.

13
0
John Dee
John Dee
3 years ago
Reply to  BeBopRockSteady

Who did the admonishing?

2
0
brachiopod
brachiopod
3 years ago
Reply to  John Dee

Billy Goates’ gruff media pals and the WHO, CDC, NIAID etc etc

7
0
Catee
Catee
3 years ago

An acquaintance told me today her four month old grandaughter is in hospital due to covid, mum’s vaccinated. I wonder if the vaccine can supress babies immune systems making them more vulnerable?

15
0
brachiopod
brachiopod
3 years ago
Reply to  Catee

I have read that while the young are at very low risk from the infection compared to the elderly, this is not the case for the very young whose immune systems are particularly immature. It may also be the case that the health of the mother – inadequate D3 etc – fails to set the baby up properly.

4
0
mwhite
mwhite
3 years ago

https://www.youtube.com/watch?v=-Y7dTMzn9B8&t=1212s

Spike Protein Gets In The Blood of Vaccinated Individuals (Firm Data From A Stanford Study)

6
0
BJs Brain is Missing
BJs Brain is Missing
3 years ago

I am so, so glad I never succumbed to the pressure and took the juice. Just coming out of a covid infection right now and I can honestly say I have had worse colds. And at least I have natural immunity from now on.

Last edited 3 years ago by BJs Brain is Missing
37
0
brachiopod
brachiopod
3 years ago

May I ask whether anyone who is still a vaccine holdout has managed to obtain a ‘Covid Recovered Certificate’ as many EU countries will now accept these at entry within 6 months of a positive test.
I know that they are automatically issued in Switzerland and EU countries, but so far over here they are hidden with the British Brexit Unicorns and Boris won’t give them either.

Anyone got one yet?

7
0
mariawarmth
mariawarmth
3 years ago
Reply to  brachiopod

an option is if you have a positive test there is a nhs online form that asks for that code given at the time of the negative. Of course this is all control and I had to test to go to work ! And you have to download the nhs app… more control

2
0
David Beaton
David Beaton
3 years ago

How obvious!

Who could have guessed? Still they don’t wake up!

5
0
TheGreenAcres
TheGreenAcres
3 years ago

Still radio adverts trying to tell me that vaccination is the ‘best choice’ for 12-15 year olds so roll up roll up for their second dose

9
0
JayBee
JayBee
3 years ago

Another nice find….
The Hubris of Modern Medicine Caused Billions to Be Injected With “Hidden Genes” in the mRNA Sequences in COVID-19 Vaccines. It’s Time We Tell Them We Know.
https://popularrationalism.substack.com/p/the-hubris-of-modern-medicine-caused

6
0
Milo
Milo
3 years ago
Reply to  JayBee

COMMENT: A WORLD GOVERNMENT UNDER THE AUSPICES OF THE WHO AND THE UN PROMISES US? – Platforma39 (domengorenseklaw.com)

and they will do precisely the same the next pandemic around and there won’t be a thing we can do about it when our sovereignty has been passed to the WHO.

0
0
timsk
timsk
3 years ago

Test.

0
0

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