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Australian Drugs Regulator Knew mRNA Vaccines Can Enter Nucleus and Integrate into Genome Despite Official Denials, Emails Reveal

by Rebekah Barnett
18 December 2024 5:07 PM

Internal emails from the Australian Therapeutic Goods Administration (TGA) reveal that the regulator withheld knowledge of DNA contamination risks relating to the mRNA vaccines from the public, presenting a picture of certainty on safety where there is none.

Released under Freedom of Information (FOI), the cache of emails shows that high-level TGA staff knew elements of the mRNA vaccines can enter the cell nucleus and integrate into the genome, despite the agency’s official line that such events are not possible.

However, TGA personnel appear more preoccupied with “allaying fears in the public” than with investigating the potential risks.

Highlights:

  • TGA staff acknowledge that DNA integration into the genome is possible
  • The TGA knows that the SV40 enhancer/promoter in the Pfizer vaccine can drag DNA into the nucleus of cells
  • Pfizer did not disclose the SV40 sequence to the regulator
  • TGA staff not aware of any testing for mRNA/DNA integration into human genome

On October 18th, the TGA published a statement, ‘Addressing misinformation about excessive DNA in the mRNA vaccines’.

The statement came after the release of a report by Canadian virologist Dr. David Speicher alleging the presence of synthetic plasmid DNA fragments in Australian vials of modified mRNA Covid vaccines at levels of up to 145 times the regulatory limit.

The issue gained national media attention after a vote by the Council of mining town Port Hedland on October 11th calling for the immediate suspension of the vaccines pending an investigation into the DNA contamination, due to the potential risks of genomic integration, cancers and other long-term health impacts.

The TGA’s statement was littered with false and misleading claims, which have been addressed in detail here. Now, emails released under FOI reveal that the TGA knowingly withheld information on DNA contamination risks from the public.

Involved in these communications were staff from the TGA’s Scientific Evaluation Branch (Toxicology and Biological Science Sections), Pharmacovigilance Branch, Communications team and even TGA boss Professor Tony Lawler, showing that personnel at the highest levels are aware of the potential risks associated with synthetic plasmid DNA in the modRNA shots.

With thanks to Dr. Melissa McCann, whose request for all TGA correspondence related to the production of the webpage and associated social media posts regarding allegations of DNA contamination in mRNA vaccines has further exposed the regulator’s duplicity on this matter.

Yes, foreign DNA can integrate into chromosomal DNA

The TGA has repeatedly stated that mRNA vaccine elements cannot enter the nucleus of cells, nor can they integrate into the genome.

Internal emails show that senior staff within the agency know this isn’t true.

On October 14th, a TGA staffer asks:

Is it even biologically possible for residual DNA at a limit of no more than 10 ng/dose to retain enough integrity from dosing to entering a cell and being enough to be incorporated into a genome for it to induce the effects that are being speculated about?

TGA FOI 25-0058 p.172

“Yes, but unlikely,” is the collective conclusion.

I cannot stress enough how contrary this is to official TGA and Department of Health messaging, which has vehemently denied that genomic integration of mRNA vaccine elements is possible at all.

Source: Department of Health
Source: SBS News
Source: Umbrella News

Initially, one TGA staffer offers the argument touted by U.S. vaccine expert Dr. Paul Offit and serially quoted by fact-checkers, including Scientific American, that foreign DNA in the mRNA vaccines cannot integrate with human DNA without the presence of an enzyme called integrase. As integrase is not present in mammalian cells, the argument goes, there is no integration risk.

TGA FOI 25-0058 p.157

However, TGA colleagues quickly debunk this claim, and it is deleted from the draft memo:

Foreign DNA can integrate into chromosomal DNA in the absence of an integrase in mammalian cells. This comes from the DNA damage/repair literature where breaks in DNA are repaired through processes called non-homologous end joining or homologous recombination. Exogenous DNA can potentially be incorporated using these processes.

TGA FOI 25-0058 p.201

From the Biological Science Section (BSS), “although unlikely, there are alternative mechanisms for DNA integration”.

TGA FOI 25-0058 p.193

And from a Senior Toxicologist:

We agree with comments raised by BSS that the original dot point on the role of integrases should be deleted. There are papers implying that other enzymes/mechanisms are involved in integrating SARS-CoV-2 sequences into the DNA of human cells (see Zhang et al. 2021).

In the end, the assertion that DNA integration is not possible is dropped from the memo, replaced with a more nebulous statement about lack of evidence:

There has been no evidence of mRNA vaccines or biological medicines resulting in integration of residual DNA into human DNA genome or causing cancer.

However, one staffer admits that he or she does not know of any science to support this statement (boldface added, here and below):

With regard to adding the comment about plasmid DNA entering the human genome, I would be uncomfortable with that as I am unaware of studies which have tested this and so personally I have no experience in the matter.

TGA FOI 25-0058 p.189

The Senior Toxicologist suggests that the statement is too speculative and perhaps should be taken out:

In the event that some aspects of the statement are too speculative, we can also omit the following sentence: “There has been no evidence of mRNA vaccines or biological medicines resulting in integration of residual DNA into human DNA genome or causing cancer.”

TGA FOI 25-0058 p.73

However, the final TGA memo retains this sentence.

Source: TGA

Under FOI request, the TGA could not provide evidence that it had examined any scientific findings related to testing for alteration of the human genome following modRNA vaccination.

“SV40 enhancer region can promote nuclear transport of DNA”

As covered at length on this Substack, scientists say that the SV40 enhancer/promoter sequence present in the Pfizer modRNA Covid vaccine poses a unique risk for genomic integration and cancer because it is particularly effective at dragging material into the nucleus of cells.

The Health Minister Mark Butler’s official position on the SV40 enhancer/promoter is that:

The TGA and the Department do not consider the presence of the SV40 promoter to be a safety concern. The SV40 promoter sequence is considered safe and is a common sequence used in biotechnology-based medicines.

But privately, TGA staff say otherwise.

“The SV40 enhancer region can promote nuclear transport of DNA,” writes a staffer in a comprehensive primer on the risks of residual DNA. This is known in the scientific community, but it is the first proof of acknowledgement from within the TGA.

TGA FOI 25-0058 p.155

The qualification follows: “Risk that this will happen is low due to low level of DNA. Risk if does happen, low as integration events have low probability.” Note that “low probability” is a different thing to “not possible”.

There is no further discussion among TGA personnel about the implications of the SV40 enhancer/promoter dragging vaccine elements into the cell nucleus of vaccine recipients, which, as shown above, officials publicly insist cannot happen.

SV40 enhancer/promoter not disclosed to TGA by Pfizer

We already know that Pfizer did not annotate the SV40 enhancer/promoter on its DNA plasmid map submitted to regulators. In Health Canada emails released under an Access to Information and Privacy (ATIP) request, an official admitted:

Pfizer has communicated to us recently, that they apparently chose not to mention this information to EMA, FDA or HC at the time of their initial or subsequent submissions.

Now we have confirmation that Pfizer didn’t mention this gene therapy sequence to the TGA either.

From the emails:

The plasmid for expression of the Pfizer mRNA was based on a pCMV-TAG vector (I used BLAST analysis of sequence from Mod3 as not all info was placed in the plasmid map provided by the Sponsor).

and,

The plasmid also contains a SV40 promoter and f1 ori region (not shown in plasmid map presented by Sponsor but found in BLAST and reported in Speicher & McKernan papers).

TGA FOI 25-0058 p.155

Discussion of risks

Conspicuously absent from the internal TGA discussion of plasmid DNA risks is the difference between naked DNA and DNA encased in lipid nanoparticles (LNPs).

As detailed in my recent Substack article, ‘No evidence for TGA’s mRNA safety claim,’ in traditional vaccines, residual DNA is ‘naked’ and can be expected to be mostly eliminated fairly quickly.

But in modified mRNA vaccines, LNPs travel to every major organ system in the body where they dump their contents into cells. Therefore, the DNA is not being destroyed before it makes it into cells.

In the case of the Pfizer vaccine, the presence of the SV40 enhancer/promoter increases the risk that this DNA, once in the cell, will be dragged into the nucleus.

The LNPs and the SV40 enhancer/promoter obviously change the risk calculation for residual DNA in mRNA vaccines.

However, while TGA staff indicate the need to address “misinformation” including the claim that, “The mRNA is different from recombinant proteins because the DNA is encapsulated in the LNPs”, at no point does anyone in the communication chain actually offer a scientific argument to refute this supposed misinformation.

TGA FOI 25-0058 p.178

Indeed, the only time the matter is directly addressed in over 200 pages of documentation is in a single paragraph:

The TGA does not hold any evidence that the residual DNA is encapsulated in lipid nanoparticles. However, if it were, there is a low safety concern with the levels present as there is a sufficient safety margin.

TGA FOI 25-0058 p.155

Previously, the TGA advised in email communications with me that, “There is no significance to minute amounts of residual DNA being encapsulated in the LNPs.”

It appears that the TGA is assuming that residual DNA, which was not successfully filtered out of the mRNA component before its packaging in LNPs, was somehow completely separated from the mRNA during the packaging process, with only mRNA being encased in the LNPs while the residual DNA just floats around naked in the rest of the vaccine mixture.

How the TGA could have arrived at such a fantastical conclusion is anyone’s guess, seeing as it was unable to provide any evidence for its stance on the insignificance of the LNPs when requested under FOI.

However, elsewhere, a TGA staffer does hint at the possibility that LNPs will contain residual DNA.

Likening the mRNA vaccines to “viral gene therapies” due to their use of high levels of DNA starting material, this person notes that, “They also have the potential to package non-target sequences and be administered to patients.”

TGA FOI 25-0058 p.75

In the risk assessment of the residual plasmid DNA provided by TGA personnel, cancer and genomic risks are acknowledged but determined to be highly unlikely. This breaks with official messaging which presents the picture of ‘no risk at all, ever’.

From the Senior Toxicologist:

There are several published papers that describe an improbable risk of oncogenicity from integration of host cell DNA from biological products, but they are considerably old (e.g. Krause & Lewis, 1998; Yang et al., 2010).

TGA FOI 25-0058 p.73

Indeed, both references are too old to have assessed the risks of modified mRNA vaccine plasmid DNA, including a nuclear-targeting SV40 enhancer/promoter, being deposited directly into cells in their LNP packaging.

Another TGA staff person, in the most comprehensive email on plasmid DNA risks, acknowledged that residual DNA can result in the inactivation of tumour-suppressor genes (leading to cancer formation), but only in high amounts.

Additionally, this staffer asserts that the smaller the DNA fragments, the lower the risk.

TGA FOI 25-0058 p.155

Once again, TGA staff seem to have forgotten that the scientific references they are referring to relate to naked DNA, not DNA packaged in LNPs and delivered straight into cells all over the body.

Note also the use of the word “contaminant” above to refer to the residual DNA, per the nomenclature of the referenced WHO Technical Report. This suggests that when the TGA says the Covid mRNA vaccines are “not contaminated“, the regulator is either playing semantics or is not sufficiently familiar with the literature on the topic.

The risk assessment summary, as below:

  • Risk of expression of genes from residual DNA low due to fragmented nature of DNA
  • Risk of oncogene expression [cancer risk] is negligible
  • Risk of replication of DNA is negligible due to fragmented DNA (no intact plasmid) and lack of recognition of ori
  • Risk of insertion is extremely low based on levels and probability indicated in datapublished by WHO, Yang etc. (still to get info re. direct injection into cells)
TGA FOI 25-0058, p.155

On the issue of DNA replication, the above mentioned email states that because the plasmid is of “bacterial origin”, this “ori” would not be recognised in human cells and so does not present a problem.

However, another staffer is less certain:

Not sure if f1 ori not recognised. May be required for replication in mammalian cells (vector appears to be dual expression vector). Does it require other components? (just thoughts)

Regardless, this person says, “the DNA is fragmented and this would be inconsequential”.

TGA FOI 25-0058 p.153

Scientists respond

“This is just overt smoke screening,” says Kevin McKernan, the genomics scientist who discovered the DNA contamination in the Covid mRNA vaccines.

McKernan, who is CSO and Founder of Medicinal Genomics, and who previously managed the R&D for the Human Genome Project at Whitehead Institute/MIT, set a few things straight in short order over email.

First, the TGA is “still not understanding the risk of LNPs and how these make the 10 ng [regulatory limit] irrelevant. All their citations are in reference to naked DNA.”

Second, the TGA is not up to date on peer-reviewed science showing DNA contamination in the mRNA vaccines over the regulatory limit (König & Kirchner 2024, and Kämmerer et al. 2024).

Third, on the assertion that smaller fragments of DNA result in lower risk, McKernan again emphasised that this is assumed for naked DNA, but not DNA wrapped in LNPs.

“When it’s naked DNA the smaller material will degrade faster. It’s not naked,” he explained. In fact, the risk increases when the DNA fragments are smaller but more plentiful.

“The smaller the DNA gets, the lower the [safety] limit needs to be as the copy number goes up,” said McKernan, pointing to a peer-reviewed article by Sheng-Fowler et al. (2009) for the Food and Drug Administration (FDA) explaining exactly this.

Source: Sheng-Fowler et al., 2009

Fourth, the chance that there is no residual DNA in the LNPs is zero. “The DNA is negatively charged and will be wrapped in LNPs for the same reason the RNA is. The cationic lipids wrap themselves around negatively charged polymers,” said McKernan.

“Kämmerer et al. demonstrate that the DNA is in the LNPs as they find it in the cells post-transfection,” McKernan added.

Persistence of the residual DNA in human cells has also been documented informally by McKernan, and by genomics scientist Dr. Phillip Buckhaults. And, most recently, plasmid DNA from the Covid vaccines was detected in blood samples from a South Australian study – this would not be possible if the residual DNA had been destroyed before making it into recipients’ cells.

Fifth, the plasmid is not just bacterial as claimed in the TGA emails, but has “mammalian origins of replication and viral elements”, McKernan clarified. This nullifies the assertion that the plasmid cannot replicate because of its apparent bacterial origin.

“The SV40 Ori is active in mammalian cells when coupled with an F1 Ori and ColE1. Both exist in the Pfizer sequence.” This is science-speak for ‘yes, this plasmid presents a replication risk in human cells’.

The regulations of 10 ng of residual DNA per vaccine dose “are now irrelevant as you can drive a truck through that regulation with LNPs containing DNA that has active mammalian origins of replication,” said McKernan in a Substack diving deeper into the ori issue.

Dr. David Speicher, the virologist who detected excessive levels of DNA contamination in both Australian and Canadian vials of the mRNA vaccines, echoes McKernan’s concerns.

“They admit that integration [of synthetic plasmid DNA] is theoretically possible,” Dr. Speicher said after reading the emails, noting the comment from one TGA staffer that the LNPs “have the potential to package non-target sequences and be administered to patients”.

Yet, “they are still applying the rules for naked DNA. While the plasmid may not have an integrase they rightly point out that ‘other mechanisms of DNA integration are possible'”.

Dr. Speicher expressed alarm that these TGA emails from as recent October 2024 raise basic questions like whether the levels of residual DNA meet the quantity and size limits, whether there are any data on residual DNA being encapsulated in LNPs (or not), and seeking to confirm what SV40 sequences are contained in the Pfizer plasmid vector.

“They should have had those answers when Pfizer submitted for regulatory approval,” said Dr. Speicher, emphasising that the Australian data alone answered these questions, showing:

  • The levels of residual DNA in the Covid mRNA vaccines are higher by both qPCR and fluorometry testing methods,
  • The residual DNA is encapsulated in the LNPs, and,
  • The presence of the SV40 enhancer/promoter.

“What strikes me is that their messaging is severe gaslighting and they are more concerned with maintaining the mantra of ‘safe and effective,’” said Dr. Speicher.

Indeed, Dr. Lisa Kerr, Assistant Secretary of the Laboratories Branch, who co-ordinated the internal communications to develop the TGA’s statement on DNA contamination ‘misinformation’ said as much.

“I’m primarily concerned with allaying fears in the public that this is actually something to worry about when it isn’t,” wrote Dr. Kerr (she/her) in the thread discussing theoretical risks that have not been clinically investigated.

TGA FOI 25-0058 p.72

Dr. Mel McCann, whose FOI request unearthed these emails, expressed dismay at what they reveal about the internal priorities of the TGA.

“Rather than contemplate the catastrophic consequence of DNA integration into the human genome or oncogenicity, the email trails focus on sanitising the public statement,” she said.

Dr. McCann said she was not surprised, but felt the emails showed “disgraceful disregard for the risk to public”.

Of course Dr. McCann should not be surprised, as lawyers representing the TGA recently argued for dismissal of the Covid vaccine injury class action she is leading on the basis that TGA officials (among others) did not owe a duty of care to Australian citizens who were injured by the medical products they approved and promoted.

Find out more about the Covid vaccine injury class action, representing over 2,000 injured Australians. If you have the means, you may consider making a donation.

This article was originally published on Dystopian Down Under, Rebekah Barnett’s Substack newsletter. You can subscribe here.

Tags: AustraliaCancerCOVID-19DisinformationDNAFreedom of InformationmRNA vaccinesPropagandaSafetyVaccine

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9 Comments
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Dinger64
Dinger64
7 months ago

Just ignore the ruling, what they gonna do? Invade?

11
0
stewart
stewart
7 months ago
Reply to  Dinger64

Withholding of funds is generally. the preferred method of enforcement.

8
0
EppingBlogger
EppingBlogger
7 months ago

Many lawyers claim the courts do not engage in legal activism or the invention of new laws where none existed before. Yet there has been no Treaty among member states to recognise novel ideas about gender and much else.

Lawyer activism it is and it is practiced here too.

8
0
Hester
Hester
7 months ago

you think there were more important things to focus on, instead the forcing of the majority to accept lies, is the ultimate tyranny

11
0
Grim Ace
Grim Ace
7 months ago

So, basically , we have to warp our societies outnof shape, ans pretend biological sex is not true, so that some manly lesbians and odd, homosexual men can feel good about themselves whilst they prance around on the world stage shouting ‘look st me! Look at me! Aren’t I self indulgent and totally narcissistic ‘

11
0
stewart
stewart
7 months ago
Reply to  Grim Ace

I don’t think this is so much about accommodating a minuscule part of society as it is about the radical transformation of society as a whole into, I don’t know what really, something very odd, very disorienting and deeply unsettling for most people.

It seems to me that that is what is being sought here, to keep people off kilter and confused. It makes people lose confidence in themselves which ultimately makes them much easier to manipulate and control.

I’m pretty sure that’s why it’s being done.

12
0
transmissionofflame
transmissionofflame
7 months ago
Reply to  stewart

Indeed – the idea that powerful people care about “trans” people or any other fashionable “victim” group they claim to worry about is quite farcical.

5
0
huxleypiggles
huxleypiggles
7 months ago
Reply to  stewart

I wholly heartedly agree 👍

5
0
soundofreason
soundofreason
7 months ago

Isn’t it amazing how a law intended to bolster trade can be twisted to undermine social values.

Lawfare.

5
0
Mogwai
Mogwai
7 months ago

It isn’t happenstance that the world is drifting this way. Whenever I read of anything like this, or the many other agendas being pushed, I always straightaway suspect the UN ( we’re familiar by now with their Agenda 2030 ) and/or WEF are behind it, those collectively referred to as the ”Globalists”, basically. We half joke about the ”woke mind virus” as a social contagion but it clearly is being orchestrated by these shady but mega-powerful ‘powers that be’.
This author has put together this amazingly comprehensive essay on the UN and their plan for global governance. It’s the first I’m hearing about this weird ‘one world religion’, mind. Anyway, here’s an excerpt from section 5, ESG and the Social Credit System;

”As I explained in this article I did for Jennifer Bilek’s 11th Hour Blog, another way ESG is being pushed is through Collaberative initiatives, like those housed at consultancy groups like Business for Social Responsibility (BSR). An example of one such collaborative is the PGLE, or Partnership for Global LGBTIQ+ Equality, which is a coalition of 29 organizations committed to leveraging their individual and collective advocacy to accelerate LGBTIQ+ equality and inclusion in the workplace globally and in the communities in which they operate. In discussing its formation at the BSR19 Conference, former head of Ernst & Young, Beth A. Brooke-Marciniak said that a few years back she and some other businesses involved in forming PGLE had a private meeting at Davos with (at the time) Vice President Joe Biden to discuss their role in pushing this agenda.

According to her, Biden sat down with these companies, looked them in the eye and said, “You companies can do what we – government – cannot, and will never do. You have to change the world on this issue.” Heeding his words, that same group of companies supported by the Office of the United Nations High Commissioner for Human Rights and operating in direct collaboration with the World Economic Forum (WEF), launched PGLE in 2019.
Because their combined wealth exceeds that of most countries, the 14 companies that started the PGLE and the ones that have joined since are able to use their financial prowess as a powerful tool to:

·        advance the LGBTIQ+ agenda by working together to “operationalize the United Nations Standards of Conduct for Business” produced in 2017 in collaboration with the Institute for Human Rights and Business. PGLE’s role is to provide tools and resources for the 400+ companies that have signed onto the UN Standards of Conduct to self-assess how they’re doing in combating discrimination against LGBTQI+ persons through scoring systems that identify gaps in their implementation of the 5 standards.

·        recommend, based on the information provided through their tools, how to close the identified gaps that exist in their implementation of the UN’s 5 Standards by strengthening policies, processes, and methodologies to support LGBTQI+ inclusivity. That may mean encouraging businesses to proudly feature a transgender person in their marketing, carrying clothing on their website or storefront that supports transgenderism, or changing their governance practices to allow men who believe that they are women into restrooms and changing spaces meant for actual women.”

https://lisalogan.substack.com/p/the-uns-master-plan-to-destroy-us?r=1hon7w&utm_campaign=post&utm_medium=web&triedRedirect=true

6
0
Mogwai
Mogwai
7 months ago
Reply to  Mogwai

https://x.com/AlanJones16178/status/1842405321610043903

1
0
huxleypiggles
huxleypiggles
7 months ago
Reply to  Mogwai

Mogs, many thanks for a very interesting link.👍

2
0
Mogwai
Mogwai
7 months ago
Reply to  huxleypiggles

It’s a bit of a behemoth, isn’t it? Not something most could sit and read all in one go, especially if you were to follow all of those hyperlinks, but fair play to Lisa Logan for spending a considerable amount of time and effort putting such a well-researched piece together. Had you heard of that strange New Age religious thing though? Perhaps that’s more pertinent to the U.S, as they have strange religions and cults over there.

1
0
JXB
JXB
7 months ago

Debauched.

4
0

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