Could someone with medical knowledge translate the following statements from this paper?
https://link.springer.com/article/10.1007/s12026-020-09152-6
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"A massive heptapeptide sharing exists between SARS-CoV-2 spike glycoprotein and human proteins. Such a peptide commonality is unexpected and highly improbable from a mathematical point of view, given that, as detailed under the “Methods” section, the probability of the occurrence in two proteins of just one heptapeptide is equal to ~ 20−7 (or 1 out of 1,280,000,000). Likewise, the probability of the occurrence in two proteins of just one hexapeptide is close to zero by being equal to ~ 20−6 (or 1 out of 64,000,000)."
"Likewise, the proteomes of the three human coronaviruses HKU1, 229E, and OC43, which were used as viral controls, have no or only a few peptides in common with the spike glycoprotein. In this regard, it seems that the SARS-CoV-2 spike glycoprotein is phenetically more similar to humans and mice than to its coronavirus “cousins”."
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It seems to be saying that the spike protein is much more similar to human proteins than it is to other coronaviruses. How could that be possible? Presumably SARS-CoV-2 mutated from other coronaviruses? Or is that not the case?
Its basically a nothing article postulating (with no real data) on the mechanism by which the spike may cause disease.
Then goes on to postulate some more that some of the methods used to test vaccines may not be accurate. ie, the animal models.
Its a nothing paper at all. Meaningless.
Could someone with medical knowledge translate the following statements from this paper?
https://link.springer.com/article/10.1007/s12026-020-09152-6
---
"A massive heptapeptide sharing exists between SARS-CoV-2 spike glycoprotein and human proteins. Such a peptide commonality is unexpected and highly improbable from a mathematical point of view, given that, as detailed under the “Methods” section, the probability of the occurrence in two proteins of just one heptapeptide is equal to ~ 20−7 (or 1 out of 1,280,000,000). Likewise, the probability of the occurrence in two proteins of just one hexapeptide is close to zero by being equal to ~ 20−6 (or 1 out of 64,000,000)."
"Likewise, the proteomes of the three human coronaviruses HKU1, 229E, and OC43, which were used as viral controls, have no or only a few peptides in common with the spike glycoprotein. In this regard, it seems that the SARS-CoV-2 spike glycoprotein is phenetically more similar to humans and mice than to its coronavirus “cousins”."
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It seems to be saying that the spike protein is much more similar to human proteins than it is to other coronaviruses. How could that be possible? Presumably SARS-CoV-2 mutated from other coronaviruses? Or is that not the case?
You've worried our vaccine enthusiast here by mentioning this paper MattO.
Interesting read. I probably would not have read it had it not been dismissed as 'meaningless'.
It simply points out that by analysis of the COV-SARS-2 spike protein there is significant similarity between human proteins. And to aged mouse proteins and to a lesser extent rats.
But not in simians, cats , dogs who are other candidates for testing vaccines targetting these.
Also the protein sequences are different from common cold coronaviruses.
One might speculate on the origins of such a virus. One might welcome such a paper which recognises the scarcity of research on likley transmissibility to humans from household pets - I can see Covid being blamed fro mass extermination of pets by chin wobblers and those who have a future control agenda.
