Regular use of ivermectin led to a 100% reduction in hospitalisation rate, a 92% reduction in mortality rate and an 86% reduction in the risk of dying from a COVID-19 infection when compared to non-users, a major new study has found.
The study, published in the medical journal Cureus, analysed data from 223,128 people from the city of Itajaí in Brazil, making it the largest study of its kind and giving its findings a high degree of certainty. Senior author Dr. Flavio A. Cadegiani wrote on Twitter: “An observational study with the size and level of analysis as ours is hardly achieved and infeasible to be conducted as a randomised clinical trial. Conclusions are hard to be refuted. Data is data, regardless of your beliefs.”
The study compared those who took ivermectin regularly, irregularly and not at all prior to being infected with COVID-19 (i.e., as prophylaxis), and found a dose-dependent relationship, confirming that the difference in outcomes is very likely to be due to the drug and not other factors, such as differences between the groups.
The authors used a technique called ‘propensity score matching’ to control for confounding factors that may otherwise have biased the study in one direction or another. For example, those taking ivermectin tended to be older than those not taking it (average age 47 years vs 40 years), but by matching people of similar age in each group and comparing outcomes this confounding factor was controlled for.
Here is the abstract of the study, which summarises the methods and results.
Background
We have previously demonstrated that ivermectin used as prophylaxis for coronavirus disease 2019 (COVID-19), irrespective of the regularity, in a strictly controlled citywide program in Southern Brazil (Itajaí, Brazil), was associated with reductions in COVID-19 infection, hospitalisation, and mortality rates. In this study, our objective was to determine if the regular use of ivermectin impacted the level of protection from COVID-19 and related outcomes, reinforcing the efficacy of ivermectin through the demonstration of a dose-response effect.
Methods
This exploratory analysis of a prospective observational study involved a program that used ivermectin at a dose of 0.2 mg/kg/day for two consecutive days, every 15 days, for 150 days. Regularity definitions were as follows: regular users had 180 mg or more of ivermectin and irregular users had up to 60 mg, in total, throughout the program. Comparisons were made between non-users (subjects who did not use ivermectin), and regular and irregular users after multivariate adjustments. The full city database was used to calculate and compare COVID-19 infection and the risk of dying from COVID-19. The COVID-19 database was used and propensity score matching (PSM) was employed for hospitalisation and mortality rates.
Results
Among 223,128 subjects from the city of Itajaí, 159,560 were 18 years old or up and were not infected by COVID-19 until July 7th 2020, from which 45,716 (28.7%) did not use and 113,844 (71.3%) used ivermectin. Among ivermectin users, 33,971 (29.8%) used irregularly (up to 60 mg) and 8,325 (7.3%) used regularly (more than 180 mg). The remaining 71,548 participants were not included in the analysis. COVID-19 infection rate was 49% lower for regular users (3.40%) than non-users (6.64%) (risk rate (RR): 0.51; 95% CI: 0.45-0.58; p < 0.0001), and 25% lower than irregular users (4.54%) (RR: 0.75; 95% CI: 0.66-0.85; p < 0.0001). The infection rate was 32% lower for irregular users than non-users (RR: 0.68; 95% CI: 0.64-0.73; p < 0.0001).
Among COVID-19 [infected] participants, regular users were older and had a higher prevalence of type 2 diabetes and hypertension than irregular and non-users. After PSM, the matched analysis contained 283 subjects in each group of non-users and regular users, [283] between regular users and irregular users, and 1,542 subjects between non-users and irregular users. The hospitalisation rate was reduced by 100% in regular users compared to both irregular users and non-users (p < 0.0001), and by 29% among irregular users compared to non-users (RR: 0.781; 95% CI: 0.49-1.05; p = 0.099). Mortality rate was 92% lower in regular users than non-users (RR: 0.08; 95% CI: 0.02-0.35; p = 0.0008) and 84% lower than irregular users (RR: 0.16; 95% CI: 0.04-0.71; p = 0.016), while irregular users had a 37% lower mortality rate reduction than non-users (RR: 0.67; 95% CI: 0.40-0.99; p = 0.049). Risk of dying from COVID-19 [once infected] was 86% lower among regular users than non-users (RR: 0.14; 95% CI: 0.03-0.57; p = 0.006), and 72% lower than irregular users (RR: 0.28; 95% CI: 0.07-1.18; p = 0.083), while irregular users had a 51% reduction compared to non-users (RR: 0.49; 95% CI: 0.32-0.76; p = 0.001).
Conclusion
Non-use of ivermectin was associated with a 12.5-fold increase in mortality rate and a seven-fold increased risk of dying from COVID-19 compared to the regular use of ivermectin. This dose-response efficacy reinforces the prophylactic effects of ivermectin against COVID-19.
The authors draw particular attention to the dose-dependent relationship as confirming the efficacy of the treatment:
The response pattern of ivermectin use and level of protection from COVID-19-related outcomes was identified and consistent across dose-related levels. The reduction in COVID-19 infection rate occurred in a consistent and significant dose-dependent manner, with reductions of 49% and 32% in regular and irregular users, when compared to non-users. The most striking evidence of ivermectin’s effectiveness was the 100% reduction in mortality for female regular users.
The data in the study come from official government databases and, according to the authors, “conclusively show that the risk of dying from COVID-19 was lower for all regular and irregular users of ivermectin, compared to non-users, considering the whole population”.
The study, while not a randomised controlled trial (RCT), used a “strictly controlled population with a great level of control for confounding factors” and was larger than would be feasible in an RCT.
The authors highlight a “notable reduction in risk of death in the over 50-year-old population and those with comorbidities”.
They conclude that the evidence provided by the study is “among the strongest and most conclusive data regarding ivermectin efficacy”.
Many governments have suppressed the use of ivermectin to treat COVID-19, claiming there is a lack of evidence of efficacy. However, this purported lack of evidence often relies on poorly designed trials and biased conclusions. For example, a recent widely-reported RCT concluded the study “did not show adequate support for the effectiveness of this drug” – yet its own results showed statistically significant benefits for speed of recovery as well as large (though not, in that study, statistically significant) benefits for mechanical ventilation and death. Participants also were not given the treatment until over a week into having symptoms and the study may have been confounded by people in the placebo arm also taking the drug.
One of the new study’s authors and a seasoned proponent of repurposed treatments like ivermectin, Dr. Pierre Kory, made clear his thoughts on Twitter in April as he responded to an FDA tweet reminding the public that ivermectin is not approved: “Messaging BS with one corrupt study while ignoring 82 trials (33 RCTs) from 27 countries, 129K patients – sum showing massive benefits. Stop lying man, people are dying. #earlytreatmentworks.”
Social media companies have censored information about ivermectin, often considering any suggestion that it is an effective treatment for COVID-19 to be misinformation. Yet ivermectin is a cheap, safe drug that many studies have shown brings considerable benefit in treating and preventing COVID-19. The latest study impressively confirms this efficacy as a prophylactic, with a reduction in mortality of up to 92%.
Shockingly, most governments still do not have a protocol for early treatment or prevention of COVID-19. The NHS says treatment is only available for those at high risk of serious disease who have a positive test and symptoms that are not getting better. Its guidance on self-care for people ill at home only recommends paracetamol and ibuprofen. Yet here is a highly controlled study of over 200,000 people that shows huge benefit – 92% reduction in mortality, 100% reduction in hospitalisation – for the prophylactic use of a cheap, widely available drug, and which confirms the results of multiple earlier studies. What are our governments waiting for? What more do they need to approve drugs that have been shown to save lives?
To join in with the discussion please make a donation to The Daily Sceptic.
Profanity and abuse will be removed and may lead to a permanent ban.
I’m confused, how does 10% of people disembarking a flight test positive, they all caught in in mid air or the tests are bogus (pre-departure, post departure, or all of the above!)?
Yeah.. half a dozen PCR tested ‘cases’ in Botswana, and within the blink of an eye the West has declared a state of emergency and are locking down borders. You’ve got to hand it to these globalists they really have got a fair sized club of useful idiots to call on..
I don’t think you’re alone. It’s what the collapse of a narrative looks like.
Collapse of the narrative?
You must be joking.
NOTHING has made sense since April 2020 when it became very apparent that the covid death was somewhere around 0.2-0.3%.
Everything since then has been the Mad Hatters Tea Party.
The death rate is a bad flu if that but we act as if it were Ebola.
The PCR test is dodgy as hell but we act as if it were dead accurate
Masks don’t do jack but we act as if they are life saving devices
The jabs don’t stop infection or transmission but we have regulations treating the jabbed as not infectious.
The jabs produce terrible side effects at an unprecedented rate but everybody denies their existence.
Footballers collapse at an unprecedented rate and we are told it’s a coincidence.
Everything is mad. Completely mad.
And you think that a story of 10% testing positive on a flight is a sign of the collapse of the narrative?
It’s just more evidence that the perpetrators of this madness can say anything they want and no one will question them.
Collapse… I wish.
I understand your pessimism Stewart but I think patience is the key here.
When I was a sceptic back in March 2020 there were very few of us, but we’ve made slow, steady progress to grow into a sizeable force against behemothic state and MSM propaganda.
The reason it’s taking so long is that many have the same mindset as those who’ve experienced fraud: it’s absolutely clear what has happened but they simply do not want to believe it.
I would like to know what tests were done on departure and on arrival, does anyone know how they test for a variant ?
Hmmm
It’s that old magician’s trick, ‘make ’em watch this hand’.
Good grief. The script seems set in stone. It’s like watching a really, really bad play, over, and over, and over… We might even call it Groundhog Play.
So I guess the zero-covid fundamentalists have access to the levers of power and are winning after all.
Every now and then someone in authority will come out and offer some platitudes about living with the virus, that it’s endemic. But behind them there is a powerful interest group with an enormous amount of power that isn’t allowing a retreat.
It’s zero-covid whether we like it or not.
Didn’t the South African doctor who discovered the new variant say it was very mild? A bit like the common cold. Perhaps we should lock down every time we get a new common cold.
I was planning suicide last year. Wrote a will and it took months to get it done because covid. Sorted now. If we’re going to do this every year I’m going to opt out. Can’t cope with months of no human contact.
Same here. I’m not prepared to live like this either! I’be spent the past 18months waking up each morning wondering what the government is going to screw us over with. Last night just made feel even worse. Really don’t want to be alive right now.
I know what it is like to feel that way, but I promise you that there will be better times; for that to happen though we have to remain defiant in the face of adversity, stick together and keep trying to find ways of getting other people to see how absurd this all is.
Take a break from all media (inc here), get more exercise and learn something new. And if you need a friend, then reach out to the people on this website to see if there is somebody local who is up for a chat, walk, coffee or beer.
I was going to ask about this. What’s the best way for us to meet new friends locally? Many of us are desparate to meet like-minded people face-to-face.
The wonderful Unjected has a dating app, which is also good for making new friends, but most users are across the pond.
There is a meet fellow sceptics section on the forums. Put up a message.
Try stand-in-the-park.
Home – A Stand In The Park
They have a list of all stands and if you went along to your local stand, you’d hopefully meet up with some like minded local people.
It’s basically people who believe in freedom standing around on a Sunday morning.
Well for a start they shouldn’t exclude the vaxxed. There are people on this site who are vaxxed but still sceptical.
It’s hypocritical – albeit understandable – for us to persecute the vaxxed for their decision when we’re rightly complaining about being persecuted for ours.
Ultimately it’s a personal decision which shouldn’t be judged by others either way.
Yes, I would advise a break from the news, including this site. There is a lot of normal life out there.
I think they will try to put pressure on us this winter, so my plan is to get through to the spring. No one should make a drastic decision at this time of year, when it gets darker every day. Wait till the spring once things open out again. I do not believe they can keep this going much longer, I think by the spring there will be too many whistleblowers, their plans will be falling apart, and things will be getting better.
I understand how you feel but all is not lost. Have courage, find like-minded people to gather with. Don’t focus so much on this. Get a pet, go for a walk, pray. God is out there and he is listening to those who cry out to him for help. All the best.
No, don’t do it. Please find a group of like-minded people. They are out there. I agree we can’t live without human contact but it’s far better to find human contact than to end it all. I can personally say I’ve felt similar but my faith in God, church family, and the opposition group I gather with weekly give me hope and encouragement. You’re not as alone as you think, please don’t let despair win.
Strangely – or perhaps, typically – over the past two years, despite everything, I’ve not dallied with suicidal ideation.
Quite the opposite.
Per Lydon, ‘anger is an energy’ and, after 19 months of this endless, circular shit-show, mine is off the charts.
I want to see some people (if you can still call them people) suffer.
And I don’t give a damn.
Anger is an energy.
That’s a t-shirt.
My blood is also boiling, I cannot wait for some people to get their redemption and I for one want to be one of the ones dishing it out
https://www.bbc.co.uk/news/business-59450418 mandatory masks in shops again from Tuesday some 4 days after the two “cases” were first detected.
We’re doomed. Doomed, I tell thee. FFS
We know nothing, except that we must proceed with maximum tyranny, based on nothing more than our own fraudulent assertions about a novel virus, which is not noticeable in society and for which there is no true evidence, but which lives in the minds of the majority we have hypnotised, so we can do what we want, and they never figure it out, so we just keep rinsing and repeating the same tired old tricks, laughing in their faces all the way.
“Omicron Variant Spreads to Denmark And The Netherlands – And Could Lead to Restrictions Tightening in Europe”
Yada yada yada
Reuters reporting Japan is at 1% of its COVID peak cases and falling. India is at 3% of its peak and falling. What did these countries do? Ditch vaccine mandates for ivermectin. Since April 28, India medical officials started providing hydroxychloroquine and Ivermectin to its massive population. As India is the major pharmaceutical manufacturer in the world, they were ready for this massive drug distribution. MIRACULOUSLY!, COVID cases have plummeted quickly since then. Meanwhile, all “first world” countries in Europe are reporting a rise in cases. Get your ivermectin before it is too late https://ivmpharmacy.com
If the Omicron variant is named after a letter of the Greek alphabet, as the Alpha, Delta, etc. strains were then it’s roughly the 15th variant of interest/concern (I’m not all that familiar with the Greek alphabet). Given that very few of the other variants became widespread it seems very suspicious that there is such a panicked over reaction to this one. Possibly the people at the heart of the conspiracy/cock up felt that project fear was starting to loose it’s effect and needed ramping up.
…possibly?
335300+ mutations and only 15 variants? (ref HART)
Enough for NY State to declare a SoE with no prior known cases; what on earth would they do if a really infectious disease broke out?
A total load of nonsense. Please read anything by Steve Kirsch on sub stack. Avoid MSM written tv or radio.
It occurred to me yesterday that the symptoms of this new variant (fatigue and s mild cough for a day or two) are about as severe as the after-effects of having one of the Covid shots, which people are perfectly willing to accept…
A perverse incentive of mandating restrictions once more, trammelling freedoms and normalising even further restrictions is herding the intelligent into inaction by discussing this issue or that issue, or whether x% is not the true figure as it is out of date.
Stop it.
All you need to know is that if this is being driven by incompetence, out they go and if it’s being driven by an agenda, out they go. It’s out they go whatever the rhetoric. You know it’s all wrong. You know it’s all unethical. You *know* it will lead to more restrictions. You know the vaccine pass will be linked to your CO2 travel footprint and your bank account via CBDCs, with 4IR just around the corner and UBI. Do something about it.
I’m not sure that there’s much point in publishing verbatim rehearsals of MSM stories like this. WE know what the narrative is.
What needs more emphasis is facts exposing the bullshit of the cold that is the ‘Omicron variant’.
Or reading this and passing on:
https://doctors4covidethics.org/long-term-persistence-of-the-sars-cov-2-spike-protein-evidence-and-implications/