27 March 2021  /  Updated 17 July 2021
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PHE : Variant Technical Briefing no. 2

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benj
Posts: 78
 benj
Topic starter
(@wade)
Joined: 1 year ago

Technical briefing no. 2 as a pdf is available from Public Health England (PHE) : Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01

This includes the Preliminary findings of matched cohort study where they compared two groups of patients, one with the previous, or wild type, of SARS-CoV-2 and the other with the variant.

For fatalities : The 28-day case fatality was assessed for variant cases and comparator cases.
Analysis was restricted to 2,700 cases with a full 28 days elapsed since the specimen
date. Among variant cases, 12 of 1,340 (0.89%) variant cases died within 28 days of
their specimen date compared with 10 of 1,360 (0.73%) wild-type comparator cases;
this difference was not signfiicant.

From the summary:
Preliminary results from the cohort study found no statistically significant difference in
hospitalisation and 28-day case fatality between cases with the variant (VOC
201212/01) and wild-type comparator cases. There was also no significant difference in
the likelihood of reinfection between variant cases and the comparator group.

10 Replies
Splatt
Posts: 1609
(@splatt)
Joined: 1 year ago

It ties in with the NervTag Update 2:-

https://khub.net/documents/135939561/338928724/New+SARS-COV-2+variant+-+information+and+risk+assessment.pdf/b56d4591-0466-1a18-28dc-010e0fdeef53?t=1608569319930

The same day Ferguson and others were squealing children are getting it more the report said no statistically significant difference in age could be found.

2 *pre-prints* out today claiming its abou 50% more infectious.
The first one is a model from Imperial authored by Ferguson so might as well treat it as bog roll.

https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-42-sars-cov-2-variant/

Second one here:-

https://virological.org/t/lineage-specific-growth-of-sars-cov-2-b-1-1-7-during-the-english-national-lockdown/575

To me they still tell us nothing - its assuming any increase in spread v existing variants means its more infectious but we know from other variants this simply isnt always the case.

A brief glance so far for me but it still seems relatively weak data wise, there's a hint but no more than that.

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Splatt
Posts: 1609
(@splatt)
Joined: 1 year ago

Actually forgot to add, if it is more transmissible its potentially self-inflicted.

By keeping up all the lockdown and distancing nonsense its quite likely we're artificially selected for a variant that CAN spread easier in those conditions.

It confers a selective advantage if it can infect with a lower viral load/have a higher load/travel further.

We're trying to fight nature and wont win.

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miahoneybee
Posts: 1541
(@miahoneybee)
Joined: 1 year ago

Nature will always win no matter how much man tries to control it. Mother nature is far more powerful.i had this conversation today with a friend.. mother nature reigns supreme..

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benj
Posts: 78
 benj
Topic starter
(@wade)
Joined: 1 year ago

2 *pre-prints* out today claiming its about 50% more infectious.
The first one is a model from Imperial authored by Ferguson so might as well treat it as bog roll.

https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-42-sars-cov-2-variant/

Second one here:-

https://virological.org/t/lineage-specific-growth-of-sars-cov-2-b-1-1-7-during-the-english-national-lockdown/575

Actually, all 7 rounds of REACT-1 community swab testing for virus are pre-prints. Nearly everything from Imperial College hasn't been reviewed independently.

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