[Mutations that increase infection and load can easily have the effect of making the host sicker and less likely to recover long term.
I think you are trying to say that lockdown provides artificial selection driving towards increased transmissibility and that, since in some cases, a mutation that increases transmissibility may also, as a side effect, increase lethality.
There is so much wrong with that it is hard to know where to start; nature already drives the virus towards increased transmissibility without lockdown, so no change. And anyway, increased transmissibility does not necessarily mean increased lethality. It may in your example, but it is only one example.
Another factor that does seem to be somewhat overlooked. Is India & many W African countries are prone to Malaria and have for many years used drugs such as, dare I say it hydroxycloroqine as anti malarials. HCQ has been confirmed to have a profound prophylactic effect on the corona-virus. It is known as the "Sunday Sunday" drug in many parts of W Africa.
Another factor that does seem to be somewhat overlooked. Is India & many W African countries are prone to Malaria and have for many years used drugs such as, dare I say it hydroxycloroqine as anti malarials. HCQ has been confirmed to have a profound prophylactic effect on the corona-virus. It is known as the "Sunday Sunday" drug in many parts of W Africa.
Thanks, Burlington, there was a trial of HCQ but it was botched. And of course now the Ernst Stavro Blofeld brigade think it was botched on purpose by giving very high doses, part of the great cover-up, leading to the great reset.
https://www.youtube.com/watch?v=2uzXHnUViro
At the moment the same rumours are swirling around ivermectin.
There is so much wrong with that it is hard to know where to start; nature already drives the virus towards increased transmissibility without lockdown, so no change.
No it doesnt. You generally have equilibrium states. Increased transmissability has limits and lots of increase one thing (for eg viral load) may have negative effects elsewhere.
In the absence of selection pressure these changes wont take off as they're held back elsewhere.
As a general rule any adaptation will have negative consequences elsewhere once that selective pressure is removed.
Certain things like immune escape can as a negative side mean less solid binding to a receptor and so on. Its selection pressure that selects for or against these changes.
By your logic every disease in history would spend all its time getting more and more transmissible as time goes on and quite clearly that doesnt happen.
And anyway, increased transmissibility does not necessarily mean increased lethality. It may in your example, but it is only one example.
It certainly doesnt mean *less* lethality which is what you claimed repeatedly. It could be positive, negative or neutral.
HCQ has been confirmed to have a profound prophylactic effect on the corona-virus. It is known as the "Sunday Sunday" drug in many parts of W Africa.
No it hasn't.
There's no solid evidence either way.
A Ioannidis meta study out recently reckons HCQ misuse early on might be responsible for up to 100k extra deaths globally.
